Towards a biologically annotated brain connectome
The brain is a network of interleaved neural circuits. In modern connectomics, brain
connectivity is typically encoded as a network of nodes and edges, abstracting away the rich�…
connectivity is typically encoded as a network of nodes and edges, abstracting away the rich�…
Convergent molecular, cellular, and cortical neuroimaging signatures of major depressive disorder
Major depressive disorder emerges from the complex interactions of biological systems that
span genes and molecules through cells, networks, and behavior. Establishing how�…
span genes and molecules through cells, networks, and behavior. Establishing how�…
[HTML][HTML] A comparison of anatomic and cellular transcriptome structures across 40 human brain diseases
Genes associated with risk for brain disease exhibit characteristic expression patterns that
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of�…
reflect both anatomical and cell type relationships. Brain-wide transcriptomic patterns of�…
Sex differences in the functional topography of association networks in youth
Prior work has shown that there is substantial interindividual variation in the spatial
distribution of functional networks across the cerebral cortex, or functional topography�…
distribution of functional networks across the cerebral cortex, or functional topography�…
Genetic, cellular, and connectomic characterization of the brain regions commonly plagued by glioma
For decades, it has been known that gliomas follow a non-random spatial distribution,
appearing more often in some brain regions (eg the insula) compared to others (eg the�…
appearing more often in some brain regions (eg the insula) compared to others (eg the�…
[HTML][HTML] Overcoming false-positive gene-category enrichment in the analysis of spatially resolved transcriptomic brain atlas data
Transcriptomic atlases have improved our understanding of the correlations between gene-
expression patterns and spatially varying properties of brain structure and function. Gene�…
expression patterns and spatially varying properties of brain structure and function. Gene�…
Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes
A key hallmark of Alzheimer's disease (AD) pathology is the intracellular accumulation of tau
protein in the form of neurofibrillary tangles across large-scale networks of the human brain�…
protein in the form of neurofibrillary tangles across large-scale networks of the human brain�…
[HTML][HTML] Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression
The neural substrates of depression may differ in men and women, but the underlying
mechanisms are incompletely understood. Here, we show that depression is associated with�…
mechanisms are incompletely understood. Here, we show that depression is associated with�…
[HTML][HTML] Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia
Brain morphology differs markedly between individuals with schizophrenia, but the cellular
and genetic basis of this heterogeneity is poorly understood. Here, we sought to determine�…
and genetic basis of this heterogeneity is poorly understood. Here, we sought to determine�…
White matter dysfunction in psychiatric disorders is associated with neurotransmitter and genetic profiles
GJ Ji, J Sun, Q Hua, L Zhang, T Zhang, T Bai…�- Nature Mental�…, 2023 - nature.com
Functional changes of white matter are largely unexplored in patients with psychiatric
disorders. This study examined white matter dysfunctions common in four major psychiatric�…
disorders. This study examined white matter dysfunctions common in four major psychiatric�…