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What We Do

Wits RHI is a hybrid research and implementation Institute that is dynamic, progressive, and responsive to global and local health emergencies. We pioneer cutting-edge science and innovation in the fields of infectious and vaccine preventable diseases; sexual and reproductive health; antimicrobial resistance,climate change and emerging crises.

Our strength lies in our multi-disciplinary and holistic approach to improving health outcomes at a local and global level through research, technical assistance, advocacy, policy development, implementation science and health systems strengthening. We identify health problems through sound epidemiological methods and qualitative research, and use a range of analytic and research methods to generate evidence and test and evaluate interventions in a real word setting.

We are a part of the the Faculty of Health Sciences at the University of the Witwatersrand (Wits), a world class African University.  We are its largest institute. 

We are a Joint United Nations Programme on AIDS (UNAIDS) and South African Medical Research Council (SAMRC) collaborating centre and a strategic partner to the United Nations Population Fund (UNFPA).

Who We Serve

Our work is focused on populations that are most in need, marginalized, or hard to reach. These include:

  • Pregnant women and mother-infant pairs
  • Women
  • Key populations including adolescents, sex workers and LGBTQI people
  • Adults and children living with HIV and TB

Where we are

Hillbrow Health Precinct

The Wits RHI head office is in the Hillbrow Health Precinct (HHP) which was established in 2004 with the aim creating a visionary, world-first environment that stands at the intersection of urban regeneration, cutting edge research and community based health care.

Since inception it has delivered outstanding health services and health care worker training, developed best practice models and implemented world class research addressing a range of critical health areas, poverty and urban renewal in Johannesburg’s inner city.

It is a model of co-operation, uniting the Gauteng Department of Health, the City of Johannesburg and Wits University represented by Wits RHI together into a unique and effective partnership.

Five previously derelict buildings have been renovated to house offices, The Shandukani and Ward 21 research sites, patient treatment clinics, three A Grade Pharmacies, and three laboratories.

South Africa

Wits RHI projects work out of 52 sites across South Africa. Most of these sites are projects where we deliver key Implementation Science and Health Programs projects, including HIV prevention, HIV and TB care to general and key populations.

Africa

We have collaborated with organisations across Africa for many years. At present we work with partners in 18 African countries.

Wits RHI in Numbers

Staff Members
2500+
Research and Implementation Sites
50
Current Active Grants
95
Academic Joint Appointments
51
Provides technological support to national, regional, and global committees (2023)
128
Published academic journals and book chapters (2023)
111
People initiated onto PrEP (2018 – 2024)
330000
People treated monthly for HIV (2023)
650000

Wits RHI Stories

Meet Amogelang Kekana

Amogelang “Sasha” Kekana is a Research Assistant for the CATALYST study within the Implementation Science Directorate at Wits RHI. She…

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AIDS 2024: New Insights on CAB-LA Safety During Pregnancy from HPTN 084

At the AIDS 2024 conference in Munich, Germany, HPTN 084 researchers presented new safety and pharmacokinetic (PK) findings for long-acting…

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Foetal Workshop
Foetal Alcohol Spectrum Disorder Workshop

Join Wits RHI Implementation Science and Maternal and Child Health Directorates in collaboration with the London School of Hygiene and…

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Our leadership

Helen Rees

Executive Director

Sinead Delany-Moretlwe

Director: Research

Thesla Palanee-Phillips

Director: Clinical Trials

Lee Fairlie

Director: Maternal and Child Health

Saiqa Mullick

Director: Implementation Science

John Imrie

Director: Health Programmes

Latest Publications

Vaccine value profile for herpes simplex virus

Authors

Johnston C, Scheele S, Bachman L, Boily M.C, Chaiyakunapruk N, Delany-Moretlwe S, Lee S, Looker K, Marshall C, Mello M.B, Ndowa F, Gottlieb S. (2024)

Abstract

Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) are chronic, highly prevalent viral infections that cause significant morbidity around the world. HSV-2 is sexually transmitted and is the leading cause of genital ulcer disease (GUD). It also increases the risk of HIV acquisition, fueling the HIV epidemic. HSV-1 is typically acquired in childhood through nonsexual contact and contributes to oral and ocular disease, but it can also be sexually transmitted to cause GUD. Both HSV-1 and HSV-2 cause neonatal herpes and neurologic disease. Given the ubiquitous nature of HSV-1 and HSV-2 infections and the limited existing prevention and control measures, vaccination would be the most efficient strategy to reduce the global burden of morbidity related to HSV infection.

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Vaccine value profile for herpes simplex virus

Johnston C, Scheele S, Bachman L, Boily M.C, Chaiyakunapruk N, Delany-Moretlwe S, Lee S, Looker K, Marshall C, Mello M.B, Ndowa F, Gottlieb S. (2024)

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Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women

Bekker LG, Das M, Abdool Karim Q, Ahmed K, Brumskine W, Gill K, Harkoo I, Jaggernath M, Kigozi G, Kiwanuka N, Kotze P, Lebina L, Cheryl E Louw CE, Malahleha…

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Effects of preterm birth, maternal ART and breastfeeding on 24-month infant HIV-free survival in a randomized trial

Dadabhai S, Chou VB, Pinilla M, Chinula L, Owor M, Violari A, Moodley D, Stranix-Chibanda L, Matubu TA, Chareka GT, Theron G, Kinikar AA, Mubiana-Mbewe M, Fairlie L, Bobat R,…

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Effectiveness of integrating HIV prevention within sexual reproductive health (SRH) services with or without peer support amongst adolescents and young adults in rural KwaZulu-Natal: Isisekelo Sempilo 2×2 factorial randomised controlled trial

Shahmanesh M, Chimbindi N, Busang J, Chidumwa G, Mthiyani N, Herbst C, Okesola N, Dreyer J, Zuma T, Luthuli M, Gumede D, Hlongwane S, Mdluli S, Msane S, Smit T,…

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Wits RHI in the News

Dr Nkosiphile Ndlovu, a Senior Research Clinician Wits RHI Research…

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At the AIDS 2024 conference in Munich, HPTN 084 researchers…

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Top-Level Medical Science in the Heart of Hillbrow," showcasing the…

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Our Donors and Partners

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