Beauty

“Botox in a bottle”: The 9 most botox-like treatments according to 3 dermatologists

No need for botox injections: these products below will nearly ensure the same effect!
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Every time we open our TikTok app, we’re inundated with a new beauty trend users can’t stop raving about. While many aren’t worth a second thought, the “Botox in a bottle” videos left us wanting to know more. Though we’re in full support of people heading to an expert for whatever cosmetic treatments suit their fancy, we’re intrigued that there might be a needle-free method right at home. So, we tapped three dermatologists to weigh in.

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What Is “Botox in a Bottle”?

“The phrase ‘Botox in a bottle’ is a term popularized on TikTok for topical products with antiaging properties that aim to reduce the appearance of fine lines and wrinkles on the face,” Dr. Tiffany Libby explains. Essentially, these promote wrinkle-reducing, plumping, and firming benefits to reveal smooth, radiant skin. According to Dr. Azadeh Shirazi, topicals work at the cellular level to enhance skin’s natural biology. “They boost vital structures like collagen, elastin, and hyaluronic acid as well as hydrating skin cells, enhancing cell turnover, and supporting the skin barrier,” she says.

What Ingredients Should You Look For?

To start, Dr. Dendy Engelman suggests that maintaining skin barrier hydration is essential to retaining plump, bouncy skin, as dehydrated skin exaggerates signs of aging. “Hydrating ingredients like hyaluronic acid, squalane, and niacinamide are key, as are ingredients that improve the skin’s ability to hold onto moisture, like ceramides and peptides,” she instructs.

Aside from hydrators, our experts emphasize the importance of utilizing ingredients that spur the production of collagen and elastin in the skin, as well as agents that protect and repair skin damage. Retinol, retinol alternatives, matrixyl, argireline, peptides, exfoliants, and antioxidants should be incorporated to see lasting results. And if it’s not said enough, Dr. Azadeh Shirazi shares again the importance of daily sun protection.

With this guidance in mind, discover an edit of skin care products that work like “Botox in a bottle.” Use them as a preventative treatment or to prolong results in between injections. “We lose approximately 1% of our collagen production in our skin each year starting in our 20s, so generally, I recommend starting to add in preventative skin care products with retinols and peptides around [that age],” Dr. Tiffany Libby says. Read on for expert-recommended products to shop.

The top products on social networks that are replacing botox

The Viral Find: The Ordinary Argireline Solution 10% and Matrixyl* 10% + HA

The Ordinary - Argireline solution 10% serum

The Ordinary - Matrixyl 10% + HA

  • Key Ingredients: We discovered this duo by The Ordinary in our TikTok scrolling, which pairs matrixyl and argireline. Of the latter, Libby explains that it works similarly to Botox injections for “its ability to reduce facial muscle contractions and help reduce wrinkles and line formation.”
  • Skin Benefits: TikTok users share that this duo helps soften facial creases and inhibit facial muscle movement, particularly atop the forehead and crow’s feet, just like Botox.
  • When to Apply: According to The Ordinary, a few drops of these can be applied twice daily—just avoid pairing them with acids, vitamin C, and resveratrol.

The clean hydrator: Biossance squalane and copper peptide rapid plumping serum

Biossance - Squalane + Copper Peptide Rapid Plumping Serum

  • Key Ingredients: “Copper peptides play a role in supporting skin structures by stimulating collagen, elastin, and hyaluronic acid in the skin,” Dendy explains of the ingredient that powers this Biossance serum.
  • Skin Benefits: So, paired with squalane, this formula promises long-lasting moisture to visibly plump skin.
  • When to Apply: According to Biossance, apply this serum morning and night to cleansed skin.

The Wrinkle-Filler: RoC Derm Correxion Fill + Treat Serum

RoC - Derm Correxion Fill + Treat Serum

  • Key Ingredients: Dr. Azadeh Shirazi, calls this a “high-value serum with retinol and multiweight hyaluronic acid that spreads nicely and absorbs quickly.”
  • Skin Benefits: This promises to visibly fill fine lines and wrinkles, while promoting a firm, supple complexion.
  • When to Apply: According to Dr. Azadeh Shirazi, , this is best applied under moisturizer at bedtime.

The Smoothing Mask: Chantecaille Bio Lifting Mask+

Chantecaille - Bio Lifting Mask+

  • Key Ingredients: Chantecaille’s mask is enriched with plant stem cells, four peptides, tensing agents, and nourishers to smooth and lift the skin.
  • Skin Benefits: This well-loved mask is known for its instant tightening effect, particularly targeting expression wrinkles, frown lines, and crow’s feet.
  • When to Apply: According to Chantecaille, this mask is best applied two to three times per week. Rinse off after 10 minutes, or leave on overnight for an intensive treatment.

The Exfoliant: Drunk Elephant T.L.C. Framboos Glycolic Resurfacing Night Serum

Drunk Elephant - T.L.C. Framboos Glycolic Resurfacing Night Serum

  • Key Ingredients: “Formulated with an AHA glycolic acid blend to renew and resurface the skin for a smoother complexion,” Shirazi says. “Salicylic acid helps loosen sebum and unclog pores, while antioxidant-rich fruit extract helps hydrate and soothe the skin.”
  • Skin Benefits: Expect smooth, luminous skin with consistent use of this Drunk Elephant serum.
  • When to Apply: Shirazi recommends applying this serum once per week.

The serum with peptides: Biba de Sousa's Plant Stem Cell serum

Biba De Sousa - The Plant Stem Cell Serum with Peptides

  • Skin benefits: Moisturizing and plumping the skin are necessary for achieving a Botox-like effect. The plant stem cell serum is an exceptional serum. Designed by renowned beautician Biba de Sousa, this lightweight elixir delivers a dose of hydration with peptides, antioxidants and hyaluronic acid to support skin radiance and firmness.
  • Key ingredients: Peptides are the stars of this formula, in particular Tripeptide-38 and Palmitoyl Tripeptide-5, which strengthen the skin barrier and stimulate collagen production respectively. Hyaluronic acid and panthenol are also present, for the aforementioned moisturizing benefits. To prevent fine lines and wrinkles, the formula uses Echinacea stem cells, while CoQ10 protects against free radical damage.
  • How to use: According to Biba de Sousa, apply a few drops of serum to the face, neck and décolleté after cleansing and toning.

Resurfacing and smoothing serum: Ourself HA+ Restoring Serum

Ourself - HA+ Replenishing Serum

  • Skin benefits: Regular use of this serum smoothes fine lines and wrinkles and improves skin elasticity. As a result, skin appears more radiant, even-toned, hydrated and firm.
  • Key ingredients: Moisturizing products, as described by Dr. Dendy Engelman, play an essential role in achieving youthful, plump skin. Two of her most recommended ingredients, hyaluronic acid and niacinamide, are present in Ourself's HA+ serum alongside peptides and vitamin C to restore skin volume.
  • How to use: According to Ourself, apply one to two pumps of serum to the face and three to four pumps to the neck and décolleté morning and evening before moisturizer.

For the neck (and décolleté):: Reserveage Beauty Firming Neck Cream

Reserveage - Beauty Firming Neck Cream

  • Key Ingredients: “Reserveage’s Firming Neck Cream is a velvety, hydrating antiaging cream that harnesses the power of microencapsulated copper peptides,” Libby says. “The exclusive microencapsulated copper peptide technology helps penetrate the skin to help maintain the look of collagen-rich skin, and reduces sagging.”
  • Skin Benefits: According to Dr. Tiffany Libby, this promises “​​to help improve skin’s tone and elasticity and minimize the appearance of fine lines.”
  • When to Apply: According to Reserveage Beauty, apply morning and night for best results.

The experts

  • Dr. Dendy Engelman is a New York City–based board-certified dermatologist and Mohs surgeon who specializes in medical and cosmetic dermatology.
  • Dr. Tiffany Libby is a board-certified dermatologist and dual-fellowship-trained Mohs surgeon and cosmetic surgeon.
  • Dr. Azadeh Shirazi is a California-based board-certified dermatologist specializing in medical, surgical, and cosmetic dermatology.

Article originally published in Vogue US.

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