Cairo’s an ancient city that also happens to be a modern metropolis—it’s one of the biggest cities in the Middle East and has the traffic and noise issues to prove it. But as long as you’re not looking for solitude, Cairo—the City of the Thousand Minarets—is a splendid place to explore Egyptian history and culture. (Editor's note: Our list was compiled before political unrest prompted many countries to issue travel warnings for Egypt. If you're currently planning a trip to Egypt, please consider the risks and monitor your government's travel alerts.)

Colombo is the gateway to Sri Lanka for most travelers—but don’t be tempted to simply pass through this diverse and interesting city. Take a train ride along the coast to Mount Lavinia, a popular beach, or explore the Talangama Wetland, which several TripAdvisor travelers say is the perfect place to take a break from the bustling streets of the city.

The sandy coast of Goa is perfect for reclining by the sea. Nestle into a cushioned chair at a beach shack and savor a curry while you sip a Kingfisher beer, watching the sun slip lazily below the horizon. In Old Goa, the beautiful Basilica of Bom Jesus is a UNESCO World Heritage Site and a fine example of baroque architecture. Visit during Christmastime to experience a fantastic religious and cultural mash-up of East and West.

Approximately 60 miles east of Antalya lies Side, another once important port town in antiquity. Side has become a popular holiday destination all by itself, but is well worth a day trip from Antalya. The village offers picturesque, narrow streets and lovely gardens while the long, white beaches invite swimming. Imposing monuments of antiquity, such as the Roman bath and the columns of the Apollo temple by the sea, complete the picture of a perfect combination of modern-day vacation pleasure and the treasures of history.

Belek, a resort town on the Turkish Riviera, is known for very clean, white-sand beaches surrounded by pine forests. History buffs should plan day trips to the Roman ruins at Perge and the Aspendos amphitheater. Or if you’d prefer a round of golf, bring your clubs—there are excellent courses in the area.

The Cyclades is a group of Greek islands with beautiful, white sandy beaches, rugged mountains and lush valleys. Glamorous Santorini and Mykonos attract the jetset, while lesser-known isles, such as Milos and Naxos, are the perfect places for beach lovers. Ruins, including the 11th-century Dorian settlement and volcanic ash-preserved Ancient Akrotiri in Santorini, amaze those with a bent for ancient history. Sifnos' cuisine wins it admirers. Hydrofoils, ferries and catamarans connect the islands.

Sprawling along the edge of the Thermaic Gulf, Thessaloniki is a seaside showcase of Greek history from ancient Roman and Byzantine ruins to the modern high-rises lining its beaches. Plus, after sundown, Greece’s cultural capital hums with some of the best nightlife options in the Aegean.

The small Brazilian village of Gramado is a quaint and woodsy respite that boasts some delightful surprises. After you’ve fully enjoyed the paddleboats and surrounding Black Forest pines of Lago Negro, pay a visit to Snowland, a unique indoor snow park. Kids will love a visit to Mini Mundo, a miniature park that features tiny replicas of famous landmarks.