True to its name, Hot Springs, Arkansas, is renowned for its thermal springs. Hot Springs National Park, and its hiking trails and bathing facilities, is the region’s starring attraction, while the city’s art deco architecture is another big draw for day-trippers from Little Rock.

The Florida Panhandle is known for its quaint beach towns and interesting attractions, many of which are money-saving and family friendly. Come to the Florida Panhandle and relax on glorious beaches, shop to your heart’s content and dance the night away. Santa Rosa Island is great for kids and offers a wide array of both beach-based and water-based activities. Families will enjoy a day away to tour the 150-year-old Pensacola Lighthouse. The Florida Panhandle offers exciting nightlife. Panama City, Destin and Pensacola all have numerous bars and nightclubs to suit all tastes. Panama City is home to Club La Vela, the largest nightclub in the U.S. The Florida Panhandle is a shopaholic’s dream. It offers specialty stores, antique stores and shopping malls. For those renting a home or condo, a trip to Joe Patti’s seafood market in Pensacola is a must. The market specializes in fine wine and cheese, and beautifully presented handmade chocolates to take home to friends and relatives as gifts. Mon Père et Moi in Tallahassee is also worth a visit.

Centrally located near all of Southern California’s major cities, Temecula Valley is the region’s wine country — with 40+ wineries offering everything from tours and events to restaurants and early-morning hot air balloon flights featuring panoramic views. Visitors also enjoy a wide range of outdoor recreational activities; the largest casino in the state at Pechanga Resort Casino; and a historic Old Town featuring wooden boardwalks, artisanal shops and restaurants, and a bustling nightlife.

Spa-goers have flocked to Carlsbad since its mineral spring was discovered in the late 19th century. Today, you can visit the site of the original well, but you can do much more than just "taking the waters"—Carlsbad’s spas offer world-class services.

Nestled between the shrub-covered slopes of the Santa Ynez Mountains and the clear blue shores of the Pacific Ocean, Santa Barbara is California at its best. Mission Santa Barbara is an example of 18th-century religious architecture, boasting beautiful grounds and a wonderfully detailed interior. Work up an appetite with a walk through Shoreline Park, then dine above the water on Stearns Wharf. Fig trees, parks, waterfalls, and botanical gardens round out Santa Barbara’s natural beauty.

Halfway between San Francisco and L.A., San Luis Obispo can be a relaxing getaway or a buzz of activity. For serenity, pack a lunch and head to one of dozens of wineries or take a drive to the beach for a leisurely swim. For a dose of history, visit the heart of the city at the beautiful Mission San Luis Obispo de Tolosa. Kids will love the Children’s Museum or Skate Park. Be sure to stroll along the creek downtown, where there are breweries, wine bars, restaurants and shopping for all tastes.

There are 2,000 years of history in Cologne, and visitors here will find everything from Roman towers to Gothic churches to fine examples of modern architecture. Cologne has a variety of museums, too—check out the Museum of Applied Art, the Museum Ludwig and, if you have a sweet tooth, the Chocolate Museum. Be forewarned, though—the gift shop at the latter will utterly ruin your diet.