Lucerne is an ancient town with strikingly modern sensibilities. One of Europe’s oldest covered bridges serves as its centerpiece, and fresco-adorned historic houses line the streets, but it’s also home to the cutting-edge KKL, a concert hall and art gallery. Take the cableways up the Pilatus, Stanserhorn or Rigi mountains for breathtaking views, or see Lake Lucerne on a steamship cruise.

A magnet for skiers and hikers, these dramatic peaks – including the iconic Matterhorn – range from 3,000 to 15,000 feet and spread across three-fifths of the country. Abundant glaciers, scenic valleys and gorgeous alpine lakes add to the region's visual appeal. The Glacier Express train travels the 7.5-hour route through the Swiss Alps from Zermatt to St. Moritz, passing through fairy-tale villages and over 291 bridges along the way.

This Italian-speaking region in Southern Switzerland is on the border with Italy. Bellinzona is the capital, and Lugano is the most important city in the canton, known for its beautiful waterfront, steep hillsides and gorgeous lake views. Castelgrande is a lovely medieval castle overlooking the city that has recently been restored. The Centovalli Railway is a scenic train that operates between Locarno, Switzerland and Domodossola, Italy, traveling through the breathtaking "Hundred Valleys." Lake Como is nearby, the home of People magazine’s “Sexiest Man Alive,” George Clooney.

The largest city in Switzerland is a major contemporary art and shopping destination. Important artworks are displayed in the Kunsthaus and the Rietberg Museum, while those who consider shopping an art can hone their skills along Bahnhofstrasse and Niederdorf. Chagall's stained glass windows in the Fraumunster amaze and Zurich's 500 clubs and bars, including several in swimming pools, pulse with life 'til the early hours. This city on Lake Zurich has excellent public transit and a free bike rental system.

Located on the Rhine River near the borders of France and Germany, Basel contains the country's highest concentration of museums. The culture-centric city, site of the world's most influential art market each June, is also home to the lovely Munster Cathedral, made of red sandstone with a multi-colored tile roof. Green spaces abound, including the popular zoological gardens in the city center. Switzerland's largest site of Roman ruins, Augusta Raurica, are an easy day trip to the east.

On the south side of the Alps, Lake Maggiore is the second largest lake in Italy. Since the climate is mild year-round, the area is filled with Mediterranean vegetation and exotic plants. Lake Maggiore was featured in Ernest Hemingway's infamous novel, A Farewell to Arms, when the protagonist and his lover must row across the lake in order to escape the Italian Carabinieri (think police in military uniforms). Here's hoping you won't have any run-ins of that nature.

The peaks of Mont Blanc, the Matterhorn and their fellow snow-capped giants make Italy's Valle d'Aosta region a haven for serious skiers and hikers. The Courmayeur resort offers year-round icy adventures, thanks to its Giant Glacier. The country's oldest national park, Gran Paradiso, is also located in Valle d'Aosta, as are numerous castles. A cable car ride from La Palud carries passengers over the mountains all the way into Chamonix, France, offering a bird's eye view of the breathtaking scenery.

Perfectly positioned on a lake with the Alps at its back, lucky Lugano has a little bit of everything. Ride a cable car up Monte San Salvatore or Monte Bre for sunny panoramas of lake, rivers, mountains and red-roofed buildings. Explore the town's churches, cathedrals and the expressive and colorful Piazza della Riforma. Sample some slow-cooked Ticinese cuisine, explore the lake on a boat or spend the day at the lido with its Olympic-sized pool.

As host of the first Winter Olympics in 1924, Chamonix will always have a place in the history books. Its main attractions are Mont-Blanc (Western Europe's tallest mountain) and the many ski areas that face the Chamonix Valley. Steep slopes and extreme weather conditions suit advanced skiers best, but there are also runs for beginners. Just make sure everyone in your party knows a green circle from a black diamond. Oh, and another note for the history books—Pierce Brosnan was here (filming a James Bond movie, The World Is Not Enough).

Home to the oldest university in Germany, Heidelberg was hit hard during 17th-century wars and rebuilt in the 18th century with baroque buildings. For a pleasant walk, stroll through the historic city center's Gothic streets. Be sure to take in Heidelberg Castle, the symbolic heart of the city; Alte Brucke, a beautiful 18th-century bridge; and the Student Jail. Built as long ago as the 16th century, it was used to keep mischievous students off the streets for three days to a month at a time. And they say Penn State is the number-one party school!

Lively Antwerp is a hidden gem. Its medieval streets, Renaissance monuments and vibrant nightlife tend to be overshadowed by its reputation as center of the diamond trade and as the world's fifth-largest port. Biking is a popular choice for getting around this stylish Flemish city. See thousands of Old Masters at the Royal Museum and Rubens House. Experience the bustle of life at the Grote Markt. Marvel at the art and architecture of the still unfinished Cathedral of Our Lady, started in 1351.

Serving as the main port town for the island of the same name, the town of Ischia has been inhabited for centuries, famous for its beaches and the healing waters of its spas. The town is divided in two: Ischia Porto is the harbor district and commercial center of the island, filled with brightly lit taverns and bars, and Ischia Ponte, the historic quarter, with its ancient castle and its stone streets seemingly frozen in time.

Nepal’s capital is surrounded by a valley full of historic sites, ancient temples, shrines, and fascinating villages. Mingle with locals and animals amid Durbar Square’s monuments, or join mountain trekkers in the bustling Thamel District. Explore shops for exquisite work by local artisans—carpets and paper prints are specialties.

During the Civil War, Knoxville's Mabry-Hazen House served as headquarters for both the Confederate and Union armies. Today you can visit the house and other historic homes in this eastern Tennessee city. Among Knoxville's other attractions are museums, a zoo and World's Fair Park, site of the 1982 World's Fair. University of Tennessee sports draw lots of fans, as does the Women's Basketball Hall of Fame. To see Knoxville from the water, take a leisurely riverboat ride down the Tennessee River.

The diverse population of Chennai (Madras) is reflected in its rich cultural scene. You’ll find serious theatre as well as the glitz and glamour of Kollywood. Chennai is also an important center for the Bharatanatyam, a local form of classical dance. Visit in January, for the festival of Pongal, or in April, when Chennai celebrates its new year.