Perfectly positioned on a lake with the Alps at its back, lucky Lugano has a little bit of everything. Ride a cable car up Monte San Salvatore or Monte Bre for sunny panoramas of lake, rivers, mountains and red-roofed buildings. Explore the town's churches, cathedrals and the expressive and colorful Piazza della Riforma. Sample some slow-cooked Ticinese cuisine, explore the lake on a boat or spend the day at the lido with its Olympic-sized pool.

Like all of the U.S. Virgin Islands, St. Thomas has plenty of opportunities to lounge on the beach, splash in the sea, or amp it up with watersports. It also boasts a bountiful duty-free shopping scene – just be prepared to brave the cruise ship crowds. Charlotte Amalie swells with Danish colonial architecture and pirate legend. Shiver ye timbers at Blackbeard’s Castle, then work up an appetite by climbing the historic 99 Steps, constructed from the ballast bricks of 18th century Danish ships.

Conquering New York in one visit is impossible. Instead, hit the must-sees – the Empire State Building, the Statue of Liberty, Central Park, the Metropolitan Museum of Art – and then explore off the beaten path with visits to The Cloisters or one of the city’s libraries. Indulge in the bohemian shops of the West Village or the fine dining of the Upper West Side. The bustling marketplace inside of Grand Central Station gives you a literal taste of the best the city has to offer.

U.S. citizens still need to jump through a few hoops to visit Cuba, but as visitors from around the world know, this island offers some amazing opportunities for cultural exchange. Havana is a mix of old-world architecture and of-the-moment culture. Head out of the capital city to the small town of Trinidad to see more Spanish colonial architecture. It’s a UNESCO World Heritage Site and a fantastic home base for a visit to the Valley of the Sugar Mills, a pocket of land that formerly served as the center of Cuba’s sugar industry.

An archipelago off the northwest coast of Panama, Bocas del Toro is an eco-tourism favorite with English-speaking and other tourists traveling to this Central American country. Seven islands (including Isla Colón, Isla Carenero and Isla Bastimentos) comprise the land area, with Bocas Town its regional capital and the “big city” for those looking to shop, dine well, and explore nightlife. Adventure lovers will find plenty to keep them occupied, as scuba diving, snorkeling, sailing, surfing and hiking are first-rate. And if you’re more of a tour-goer, never fear—Bocas del Toro offers a host of them, ranging from sailing to Nivida Bat Cave tours.

It has been said that Birmingham is the last major Southern city in America, where a friendly "How y'all doin'," a hearty meal of country-fried steak with butter beans and a true taste of Southern hospitality await visitors. Whether you're into the history of the Civil Rights movement, a fan of jazz music or just looking for culture and a few fun activities for the family, Sweet Birmingham is the place for you. Spend the morning at the Birmingham Museum of Art, then have lunch at a traditional Southern tea room. Outdoor enthusiasts can tee off at the Robert Trent Jones Golf Trail or pack a lunch and spend the day hiking and enjoying the vistas at Ruffner Mountain. A world-class zoo, the innovative McWane Center and VisionLand, Alabama's first amusement park, are sure to keep families entertained and on the go. In the evening, listen to a blues show at an outdoor cafe and then spend the night at a small cozy inn or splurge for an elegant hotel.

Today the capital city and cultural center of Iowa is revitalized. A versatile destination everyone will enjoy, Des Moines has an itinerary for almost every interest. Culture and art enthusiasts may want to roam through the Des Moines Art Center, spend the weekend museum-hopping or attend a Broadway-caliber performance at the Civic Center. Golfers can spend their time and energy teeing up at any of the area's fine championship courses. The Blank Park Zoo and the Iowa State Fairgrounds should be on the list for families. And gardeners will savor the fantastic blooms at the Botanical Center and the Better Homes and Gardens Test Garden. Mix it up a little and sample all this "big city with a small town heart" has to offer.