Vines, wines and the people who love them are central to the economy of Napa Valley. Other treats for taste buds are in store, too, in the form of local olive oils, tomatoes, cheeses and mustard. The other senses are catered for with a vibrant visual arts scene. Rent a car or book a taxi or limousine to get between sights safely. The Napa Valley Wine Train offers an unusual way to experience the views and vintages. A relaxing array of spas and mud baths and the Old Faithful geyser are attractions in Calistoga.

Gold and silver may have been behind the hordes that flocked in the 1800s, but liquid gold - Chardonnays, Cabernet Sauvignons and Pinot Noirs - is behind the modern migration. This dream destination for wine lovers has an abundance of fine restaurants and inns. Horse posts have been replaced by bike racks, and pedal power is a great way to explore.

Every neighborhood in San Francisco has its own personality, from the hippie chic of the Upper Haight to the hipster grit of the Mission. The Marina district boasts trendy bistros and postcard-perfect views of the Golden Gate Bridge, while Noe Valley offers quaint and quiet boutiques. Wave hello to the sea lions at Pier 39, and sample local cheese and charcuterie at the Ferry Building. Sit in on a yoga session in Dolores Park or marvel at the Dutch Windmill across from Ocean Beach.

California's capital city is often overlooked by tourists seeking out better known destinations in other corners of the state. Look again: Sacramento offers a range of exciting, educational and historic attractions sure to entertain all. Families will want to check out the cheetahs, jaguars and crocodiles at the Zoo while political buffs should head to the state Capitol, which features a park and museum on California history, or the Governor's Mansion. Anyone with an interest in trains will enjoy the Railroad Museum's massive collection of antique locomotives. Everyone will enjoy the restaurants and shops of historic Old Sacramento on the city's lovely waterfront.

With its ideal location on the magnificently rugged Oregon Coast, the entire city of Newport is a natural observatory that offers a number of fun and educational activities for the whole family. Spend the morning exploring tide pools, combing the beach for fossils and spotting marine life in their natural habitats. Then head over to the Oregon Coast Aquarium where you can pet an octopus and walk through a glass tunnel surrounded by sharks. Newport is also home to two lighthouses, one of which is the tallest on the Oregon Coast. Historic Nye Beach, with its colorful cottages and laid-back atmosphere, is the perfect spot for a picnic and a quick rest from all the sightseeing.

Desert meets sea in Puerto Penasco, a California Gulf getaway. With its seafood markets, snoozy streets, and sandy beaches, it's easy to see how the port town has retained its traditional charm. There's something for everyone, from nature parks and water sports to upscale resorts.

The Florida Panhandle is known for its quaint beach towns and interesting attractions, many of which are money-saving and family friendly. Come to the Florida Panhandle and relax on glorious beaches, shop to your heart’s content and dance the night away. Santa Rosa Island is great for kids and offers a wide array of both beach-based and water-based activities. Families will enjoy a day away to tour the 150-year-old Pensacola Lighthouse. The Florida Panhandle offers exciting nightlife. Panama City, Destin and Pensacola all have numerous bars and nightclubs to suit all tastes. Panama City is home to Club La Vela, the largest nightclub in the U.S. The Florida Panhandle is a shopaholic’s dream. It offers specialty stores, antique stores and shopping malls. For those renting a home or condo, a trip to Joe Patti’s seafood market in Pensacola is a must. The market specializes in fine wine and cheese, and beautifully presented handmade chocolates to take home to friends and relatives as gifts. Mon Père et Moi in Tallahassee is also worth a visit.

Long known as a golfer's paradise, Hilton Head Island is heaven for any type of sports enthusiast. Tennis, volleyball, polo, championship golf on some of the best fairways in the United States - those are just a few athletic options. In fact, the island plays host to many prestigious sporting events throughout the year. All of it surrounded by sunny beaches and lush greenery. In between games or matches, explore Hilton Head's natural wonders. The Sea Pines Forest Preserve offers a close-up look at a swamp without having to get mucky. Raised boardwalks provide a protected path for pedestrians. And don't miss the colorful Harbourtown Lighthouse, the island's icon. Choose from a number of first-class resorts and hotels to experience it all.

Although much of Jacksonville is urban, this sprawling northeastern Florida city also has nature and wildlife preserves, historic residential neighborhoods and lots of golf courses. Attractions in Jax, as the locals call it, range from art, science and history museums to a brewery tour, from the Jacksonville Landing entertainment complex, along the St. John's River, to Bronson Motor Speedway. The city's beaches offer soft sand and warm water perfect for swimming, surfing and kayaking.

A rich 300-year history, a thriving arts community and seemingly endless wilderness make this New York capital city on the Hudson River a great weekend getaway. Outdoor enthusiasts come here to ski, hike, canoe and fish; trout and small-mouth bass fishing is among the best in the U.S. Mountains surround the city, and the tapestry of golds and reds on an autumn day is breathtaking. The city is dominated by an elaborate 10-building complex that includes the State Capitol; the New York State Museum, with life-like dioramas such as American Indian life and an Adirondack logging operation; and the oval-shaped Empire State Performing Arts Center, nicknamed "The Egg." History buffs will enjoy the colonial homes, historic churches and museums, and can tour 18th-century mansions, like the Schuyler, a superb example of pre-Revolutionary War architecture. Whether nature or history is your passion, you'll find an abundance of both in this upstate New York gem.

Just ten miles west of Ocho Rios, Runaway Bay's stunning beaches see far fewer footprints than its neighbors. It's also removed from the cruise ship herds and pushy vendors. Perfect for those happy not to wander far from their resort, there are a few nearby attractions nonetheless. Bob Marley's childhood home and mausoleum is in nearby Nine Mile. Jamaican history is on view at Seville Great House and at Columbus Park Museum. To explore, rent a reliable vehicle and remember to drive on the left.

With equal efforts dedicated to wildlife preservation and a beach-getaway atmosphere, Manuel Antonio has surely earned its reputation as one of Costa Rica's most gorgeous locales. A lively resort town sits just north of a national park, where a rain forest teeming with monkeys resides.