Greenville, South Carolina, is a welcoming place to shop, dine, see historic homes and watch minor-league sports. The city is also home to significant art collections and a vibrant performing-arts scene. Families can enjoy child-friendly activities such as searching for nine bronze mice scattered around the city, visiting the Greenville Zoo, relaxing in the many outdoor spaces and enjoying numerous annual festivals. State parks and Revolutionary and Civil War sites are a short drive away.

It has been said that Birmingham is the last major Southern city in America, where a friendly "How y'all doin'," a hearty meal of country-fried steak with butter beans and a true taste of Southern hospitality await visitors. Whether you're into the history of the Civil Rights movement, a fan of jazz music or just looking for culture and a few fun activities for the family, Sweet Birmingham is the place for you. Spend the morning at the Birmingham Museum of Art, then have lunch at a traditional Southern tea room. Outdoor enthusiasts can tee off at the Robert Trent Jones Golf Trail or pack a lunch and spend the day hiking and enjoying the vistas at Ruffner Mountain. A world-class zoo, the innovative McWane Centre and VisionLand, Alabama's first amusement park, are sure to keep families entertained and on the go. In the evening, listen to a blues show at an outdoor cafe and then spend the night at a small cozy inn or splurge for an elegant hotel.

Lively Antigua and Barbuda move to the music of steel drums. You can visit a different beach each day and not repeat yourself for a full year—and that's why tourists and celebrities alike flock to this sun-soaked Caribbean island. Take a day cruise, rent some diving gear or cruise up the beach on a Segway for a real adventure, island-style.

Quepos, a small town in Puntarenas province, is located on Costa Rica’s central Pacific coast and is undoubtedly one of the best places in the world for big game sport fishing. However, Quepos also offers vacationers a wealth of other activities to do as well. The nearby plaza has many fine restaurants, art galleries and souvenir shops, most within a short walking distance of your beachfront vacation rental. Book an exhilarating canopy tour, go horseback riding, kayaking and rafting. Learn to surf or watch the surfers ride the waves; you’ll wonder at their athleticism.

Astounding natural wonders, invigorating outdoor recreation and fascinating cultural attractions make Flagstaff the perfect getaway to rejuvenate the body and replenish the mind. Set at the base of the beautiful San Francisco Peaks, and surrounded by lush national forests, the city provides ample opportunity for fresh air fun. Spring, summer and fall bring hikers, campers and mountain bikers, while winter draws skiers and ice skaters. But don't let a focus on the "good old outdoors" fool you. Fostered by the local university, Flagstaff is also chock-full of educational and cultural attractions. Be sure to see the award-winning permanent exhibit "Native Peoples of the Colorado Plateau" at the Museum of Northern Arizona. The Pioneer Museum offers a glimpse of what life was like for the early settlers of the region and includes a 1929 Baldwin locomotive in its collection. The city also has an arboretum and a planetarium. The entire area is a living anthropology and geology lesson, with ancient Native American ruins and stunning scenery at the Wupatki and Walnut Canyon National Monuments, just waiting to be explored.

Touching Belgium on its west and just a few miles from Germany to the east, Maastricht is the capital of Holland’s southernmost region, Limburg. A town rich in history and culture, Maastricht boasts two wonderful town squares: Vrijthof, with Sint-Servaas Church, Sint-Jan's Cathedral and many bars, cafes and restaurants; and Markt, home to the town hall and, on Wednesday and Friday mornings, a fantastic vendor market. The city’s Vestigingswerken, or old town fortifications, are another big draw.

There are 2,000 years of history in Cologne, and visitors here will find everything from Roman towers to Gothic churches to fine examples of modern architecture. Cologne has a variety of museums, too—check out the Museum of Applied Art, the Museum Ludwig and, if you have a sweet tooth, the Chocolate Museum. Be forewarned, though—the gift shop at the latter will utterly ruin your diet.