The history of St. Louis has been heavily influenced by Westward expansion and blues music. The big "must-see" in this region is the Gateway Arch, while other important sites include the Museum of Westward Expansion, the St. Louis Cathedral and the Anheuser-Busch factory tour. The city offers plenty for the whole family. Children will enjoy the local zoo and the Magic House, while family members will also want to unwind at Forest Park, home to the World's Fair almost a century ago.

The Clintons may have put Little Rock on the map, but this charming and historic capital city offers plenty of reasons to keep it there. The Central High Museum tells the painful, powerful story of the city's racial struggles. Political buffs and Clinton fans will want to check out the State Capitol. Shoppers can spend hours at the River Market, a collection of tasty eateries and eclectic stores. Kids will be more than wowed by attractions such as the Children's Museum, the Museum of Discovery and the Zoo, famous for its eye-popping ape exhibit. Stay at a charming historic abode, an inviting bed and breakfast or a luxury hotel. Eat at fabulous restaurants and enjoy exciting nightlife. Little Rock has all the ingredients of a perfect weekend getaway.

You may have all heard that everything is bigger in Texas. Well, Dallas does its best to fulfill that promise. You'll find several museums with vast art collections and fascinating specialty museums like The Sixth Floor Museum/Texas School Book Depository, which, though small in size, offers an immense amount of information about the assassination of John F. Kennedy. And of course, visit a local steakhouse for a terrific (and enormous) meal.

Astounding natural wonders, invigorating outdoor recreation and fascinating cultural attractions make Flagstaff the perfect getaway to rejuvenate the body and replenish the mind. Set at the base of the beautiful San Francisco Peaks, and surrounded by lush national forests, the city provides ample opportunity for fresh air fun. Spring, summer and fall bring hikers, campers and mountain bikers, while winter draws skiers and ice skaters. But don't let a focus on the "good old outdoors" fool you. Fostered by the local university, Flagstaff is also chock-full of educational and cultural attractions. Be sure to see the award-winning permanent exhibit "Native Peoples of the Colorado Plateau" at the Museum of Northern Arizona. The Pioneer Museum offers a glimpse of what life was like for the early settlers of the region and includes a 1929 Baldwin locomotive in its collection. The city also has an arboretum and a planetarium. The entire area is a living anthropology and geology lesson, with ancient Native American ruins and stunning scenery at the Wupatki and Walnut Canyon National Monuments, just waiting to be explored.

Puerto Morelos, a peaceful village on the Mayan Riviera, is a place to experience the genuine Yucatan. Puerto Morelos makes an excellent base if you’re looking for someplace quieter than glitzy hotspots like Cancun and Playa del Carmen. Government eco-reserve designations protect the reef and mangroves—and the village itself—from development. Outdoor options range from thrilling jungle and diving adventures to serene bike rides or moped explorations.

The soundtrack of tranquil Boa Vista is the sweet tweets of exotic birds. Maybe they’re chattering with loggerhead turtles or with the humpback whales that are known to splash around Boa Vista’s shallow waters. Work up a sweat and hike to the wreck of the Santa Maria, or explore the Duque de Braganca Fort, built to protect the Ilheu de Sal Rei from pirates. The windswept red and tan sand dunes of Deserto de Viana are awe-inspiring.

The city of Freiburg im Breisgau sits austerely on the edge of the Black Forest. Home to one of Germany’s oldest universities and a Gothic sandstone cathedral, it’s a hub for academics and medieval history buffs. Chug German suds at a local brewery, then hop a cable car up Schauinsland mountain, where astounding views and a solar observatory await.