BARBARA BUSH

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Global Health Corps

Grand Plan: Improve health in developing nations via her Global Health Corps, a sort of Teach for America movement.

Making Headlines: The 34-year-old former first daughter's organization is attracting young people in droves: 6,000 apply for 150 spots in the yearlong paid fellowship. Recent projects have included creating a medicine supply chain in Tanzania and designing clinics in Rwanda that have controlled airflow to minimize the spread of tuberculosis.

EMILY TISCH SUSSMAN

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Donna Newman

Grand Plan: Reduce gun violence, among other things.

Making Headlines: As campaign director for DC-based think tank Center for American Progress, the 34-year-old lawyer daughter of Laurie Tisch isn't just in the news—she's on it, regularly contributing to Fox News, MSNBC, and others, advocating for anti–gun violence measures and other policy initiatives.

MATTHEW REEVE

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Ilya S. Savenok/Getty Images

Grand Plan: Cure paralysis caused by spinal cord injury, as his parents sought to do before him.

Making Headlines: Christopher Reeve's oldest son, Matthew, 35, is keeping Dad's legacy alive as vice chairman of international development at the Christopher & Dana Reeve Foundation. Its Big Idea campaign to fast-track the next phase of epidural stimulation research has enabled four young men, completely paralyzed, to stand and to voluntarily move their legs while a device is activated.

JUSTIN ROCKEFELLER

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Stephen Lovekin/Variety/Rex/Shutterstock

Grand Plan: Convince the wealthy not only to invest their money in a socially responsible manner but to do it more effectively.

Making Headlines: In 2013 the 36-year-old scion of the famous family helped form The ImPact, a Giving Pledge–type commitment to impact investing; signers include Hyatt heiress Liesel Pritzker Simmons and billionaire entrepreneur Jim Sorenson. The ImPact CEO Abigail Noble raised eyebrows in a Tedx Talk when she said people compare impact investing to high school sex: "Everyone is talking about it. Very few people are actually doing it. And those who are doing it aren't doing it all that well."