There is no link between a suspected cluster of a rare condition of the peripheral nervous system in Duleek, Co Meath and the three industrial plants in the town, an HSE report has found.
It followed the identification of three people living in Duleek who developed Guillain-Barré syndrome between 2010 and 2014.
Locals were concerned that the number of cases of the disease in a town of just over 7,000 inhabitants was linked to environmental issues in the area.
It is estimated that there are between 50 and 100 new cases of Guillain-Barré syndrome in Ireland each year.
The HSE review confirmed three cases of people living in Duleek with the syndrome, although locals had reported six suspected cases.
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The report said that the numbers were in keeping with the expected incidence of the disease over the time period.
The Environmental Protection Agency and Meath county council found no evidence of any non-compliance at any of the sites — an Irish Cement plant, an Indaver incinerator and a Eurofarms abattoir as well as a sewage treatment facility.
The review said that the three people who developed the condition had a history of an infection shortly before the onset of their symptoms.