A PRF treatment uses platelet-rich fibrin (PRF) to rejuvenate skin or hair. PRF has a high concentration of both platelets and growth factors, which can help cells function better and trigger stem cell activity to spur elastin and collagen production, promote hair growth, and accelerate the wound healing process.
Recent research supports the benefits of PRF for tissue repair, and it’s often combined with cosmetic procedures like microneedling (a combo sometimes called a PRF facial), fat transfer, and hyaluronic acid-based dermal fillers. It can be applied topically or injected into skin (often referred to as i-PRF, short for injectable PRF) to target signs of aging.
The most common treatment areas for PRF are the face (especially dark under-eye circles), neck, and hands. According to board-certified plastic surgeon Dr. Stephen Greenberg, “PRF is great for patients with thin skin, crepey skin, and under-eye discoloration.”
Benefits of PRF include:
PRF injections in the scalp can enhance hair growth and address hair loss in patients with thinning or androgenetic alopecia.
Sports medicine providers also use PRF therapy to treat joint pain and accelerate healing.
RealSelf Tip: There’s a misconception that PRF injections are a “natural” substitute for fillers, but PRF doesn’t add volume, so “it does not replace filler,” says Dr. Greenberg. “Rather, it’s used as an adjunct to dermal fillers to improve skin integrity.”
PRF is considered the second generation of platelet concentrations—the first being platelet-rich plasma, or PRP.
“PRP and PRF are regenerative, platelet-based treatments,” says Dr. Greenberg. “They are both harvested the same way, but treated differently afterwards.”
First, a provider will draw your own blood from your arm. Then it will be processed in a centrifuge.
Typically, PRF is processed without any additives like anticoagulants (which some say have the potential to impair wound healing). It forms a fibrin matrix that helps confine the release of growth factors, white blood cells, and other nutrients to the treatment site, while stimulating new collagen production.
In terms of results, PRF seems to outperform PRP. A 2023 study comparing PRF to PRP found that PRF—used both alone and alongside microneedling—led to a more significant improvement in acne scars than PRP, potentially due to the high number of growth factors. Another paper found that the results of PRF were comparable to PRP when injected into skin, but PRF results lasted a few months longer.
Pros
Cons
PRP treatments can cost anywhere from $300 to $2,500 per session.
The price you pay will depend on:
Start with a consultation to align on your treatment plan. Then ask for a detailed cost quote that includes all related fees.
Standards and protocols for how best to prepare PRF for skin and hair rejuvenation are still being developed, but the process typically looks something like this, according to Dr. Greenberg:
Because there’s so much variability in how PRF treatments are being performed, it’s wise to have a detailed consultation prior to your session, so your provider can talk you through the details of their protocol.
For the face, Dr. Greenberg recommends a series of three treatments, spaced six to eight weeks apart for optimal results. After that, your provider may recommend one to two treatments a year to maintain your results.
For hair loss, expect to need about four monthly sessions, followed by two or three maintenance treatments annually.
Your provider may suggest a different treatment plan, depending on your concerns, goals, and budget.
Studies on the effectiveness of PRF for hair loss and skin rejuvenation are scant, but the scientific evidence so far is promising:
In one small study published in 2023, PRF under eye treatment results were still visible 3 months later. Improvements included a reduction in wrinkles and hyperpigmentation, along with a “refreshed appearance.”
PRF results last longer when paired with other procedures. For instance, one study found that PRF treatments paired with nanofat transfer lasted at least one full year. According to the authors, “improvements were sustained for more than 12 months in the test group compared with 1 month in the control group.”
So far, PRP seems to be very safe, says Dr. Greenberg. The most common PRF side effects are minor bruising, swelling, and redness at the injection site. The under-eye area can be especially prone to swelling, which may linger for up to five days.
As with any injection, you may have some inflammation and soreness, but it should subside within a few hours.
Updated December 7, 2023