Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Targeting divergent pathways in the nutritional management of depression

Derek Tobin

Alex Vuckovic

^* ,

Jerome Sarris

Version 1 : Received: 17 June 2024 / Approved: 18 June 2024 / Online: 18 June 2024 (13:37:09 CEST)

How to cite: Tobin, D.; Vuckovic, A.; Sarris, J. Targeting divergent pathways in the nutritional management of depression. Preprints 2024, 2024061247. https://doi.org/10.20944/preprints202406.1247.v1 Tobin, D.; Vuckovic, A.; Sarris, J. Targeting divergent pathways in the nutritional management of depression. Preprints 2024, 2024061247. https://doi.org/10.20944/preprints202406.1247.v1

Abstract

Nutritional management of depression has long been discussed due to the perceived benefit of a nutritional product having less side effects than pharmaceutical agents. Candidate nutrients for managing depression include Vitamin D, B-vitamins, tryptophan, branch chain amino acids, probiotics, omega-3 fatty acids, folate/methylfolate (aka Vitamin B9), and s-adenosylmethionine. This paper reviews three nutrients which have significant scientific support for the management of depression and have evidence of low levels in subjects with depression, and that correction of the nutritional deficiency provides clinical benefit. We present epidemiological evidence, mechanistic explanation and a review of interventional studies for these nutrients. Finally, relevant nutritional guidelines are presented with their conclusion for the role of each nutrient in the management of depression.

Keywords

Depression; nutrition; omega-3; EPA; methylfolate; s-adenosylmethionine, SAMe.

Subject

Medicine and Pharmacology, Dietetics and Nutrition

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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