Great Lakes Road Trip Itinerary: Travel Guide To Exploring The Region. The Great Lakes, massive freshwater lakes that almost appear to resemble the ocean based on their sheer size, are certain to amaze. This road trip starts in Chicago, Illinois, takes you north up Wisconsin and into the Upper Peninsula of Michigan, continues around the peninsula, and then down Michigan, along the northern coastline of Ohio, northeasterly to Niagara Falls, and ends in Toronto.
