Connecting Research and Experts with Journalists

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Live from the annual conference of the Association for Diagnostics & Laboratory Medicine (ADLM, formerly AACC), experts will discuss how the new FDA rule on laboratory developed tests will hinder patient care. This rule will place these tests under duplicative FDA oversight, even though laboratory developed tests are already regulated by the Centers for Medicare & Medicaid Services. This will force many labs to stop performing these essential tests, which play a critical role in diagnosing rare disorders, such as inherited genetic conditions in newborns.

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New drug that disrupts two cellular targets would make it much harder for bacteria to evolve resistance

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In 2022, Alaggio and colleagues revised the WHO Classification of Haematolymphoid Tumors resulting in elimination of the provisional diagnostic categories of Hairy Cell Leukemia Variant (HCLv) and B Prolymphocytic Leukemia.

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There’s still much to learn about how doxorubicin, a 50-year-old chemotherapy drug, causes its most concerning side effects. While responsible for saving many lives, this treatment sometimes causes cardiac damage that stiffens the heart and puts a subset of patients at risk for future heart failure. To better understand and potentially control such complications, Tufts University School of Medicine and Tufts Graduate School of Biomedical Sciences researchers have isolated the immune cells that become overactive when patients take doxorubicin.

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En un estudio publicado en ACS Central Science, los investigadores han identificado una estrategia para diseñar opioides más seguros. Han demostrado que un opioide experimental, que se une a un sitio no convencional del receptor, suprime el dolor en modelos animales con menos efectos secundarios, especialmente los vinculados a sobredosis fatales.

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Researchers at Washington University School of Medicine in St. Louis report that psilocybin, the active ingredient in magic mushrooms, destabilizes a critical network of brain areas involved in introspective thinking. The findings provide a neurobiological explanation for the drug’s mind-bending effects.

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In a pioneering study, scientists have decoded the genetic blueprint of Saposhnikovia divaricata, a traditional medicinal herb. The research provides a detailed genome sequence, shedding light on the plant’s evolutionary adaptations and the genetic foundations of its therapeutic benefits.

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In a study in ACS Central Science, researchers have identified a strategy to design safer opioids. They showed that an experimental opioid, which binds to an unconventional spot in the receptor, suppresses pain in animal models with fewer side effects — most notably those linked to fatal overdoses.

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A recent study has developed nanovesicles (NVs) from activated neutrophils, showcasing their ability to perform molecular debridement and accelerate healing in infectious wounds. This novel method significantly enhances treatment effectiveness, particularly for stubborn diabetic wounds, by targeting and neutralizing deep tissue pathogens.