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Gene therapy could prevent the tau tangles linked with Alzheimer's

Tests on lab-grown “mini-brains” show a one-off gene therapy treatment can prevent the formation of the tau tangles associated with several neurodegenerative conditions

By Michael Le Page

8 July 2024

Several neurological conditions are linked with abnormal protein tangles in brain cells

Gorodenkoff/iStock/Getty​ Images Plus

It might be possible to treat a range of neurodegenerative conditions, including Alzheimer’s disease, with a one-time gene therapy that makes brain cells produce antibodies. Tests on human “mini-brains” growing in a dish show that these antibodies can reduce levels inside brain cells of the tau protein associated with these diseases.

“We’re looking at hopefully a ‘one and done’ approach,” says David Butler at the Neural Stem Cell Institute, a non-profit organisation in New York state.

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