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Review
. 2024 Jun 25:2024:7713590.
doi: 10.1155/2024/7713590. eCollection 2024.

Connecting the Dots: Exploring the Interplay Between Preeclampsia and Peripartum Cardiomyopathy

Khanisyah Erza Gumilar  1   2 , Khairunnisa Binti Abd Rauf  2 , Muhammad Ilham Aldika Akbar  1   2 , Nareswari Cininta Imanadha  1   3 , Susetyo Atmojo  4 , Alisia Yuana Putri  5 , Erry Gumilar Dachlan  1   3 , Gus Dekker  6
Affiliations
Review

Connecting the Dots: Exploring the Interplay Between Preeclampsia and Peripartum Cardiomyopathy

Khanisyah Erza Gumilar et al. J Pregnancy. .

Abstract

Preeclampsia and peripartum cardiomyopathy (PPCM) are significant obstetric problems that can arise during or after pregnancy. Both are known to be causes of maternal mortality and morbidity. Several recent studies have suggested a link between preeclampsia and the pathophysiology of PPCM. However, the common thread that connects the two has yet to be thoroughly and fully articulated. Here, we investigate the complex dynamics of preeclampsia and PPCM in this review. Our analysis focuses mainly on inflammatory and immunological responses, endothelial dysfunction as a shared pathway, and potential genetic predisposition to both diseases. To begin, we will look at how excessive inflammatory and immunological responses can lead to clinical symptoms of both illnesses, emphasizing the role of proinflammatory cytokines and immune cells in modifying vascular and tissue responses. Second, we consider endothelial dysfunction to be a crucial point at which endothelial damage and activation contribute to pathogenesis through increased vascular permeability, vascular dysfunction, and thrombus formation. Finally, we examine recent information suggesting genetic predispositions to preeclampsia and PPCM, such as genetic variants in genes involved in the management of blood pressure, the inflammatory response, and heart structural integrity. With this synergistic study, we seek to encourage more research and creative therapy solutions by emphasizing the need for an interdisciplinary approach to understanding and managing the connection between preeclampsia and PPCM.

Keywords: endothelial dysfunctions; genetic; inflammatory; peripartum cardiomyopathy; preeclampsia.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
(a) Management algorithm for preeclampsia. (b) Antihypertensive therapy for nonurgent control of hypertension in pregnancy (modified from Magee et al.) [11]. (c) MgSO4 protocol in preeclampsia (modified from Brown et al.) [13].
Figure 2
Figure 2
Shared pathophysiology between preeclampsia and PPCM.
See this image and copyright information in PMC

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