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Clinical Trial
. 2024 Jun 1;24(1):645.
doi: 10.1186/s12903-024-04379-3.

Rebamipide gargle and benzydamine gargle in prevention and management of chemo-radiotherapy and radiotherapy-induced oral mucositis in head and neck cancer patients (randomized clinical trial)

Basma Elsaadany  1 , Samah M Anayb  2 , Karim Mashhour  3 , Mohammed Yossif  4 , Fat'heya Zahran  2
Affiliations
Clinical Trial

Rebamipide gargle and benzydamine gargle in prevention and management of chemo-radiotherapy and radiotherapy-induced oral mucositis in head and neck cancer patients (randomized clinical trial)

Basma Elsaadany et al. BMC Oral Health. .

Abstract

Objectives: This study aimed to evaluate the preventive and therapeutic effects of rebamipide gargle in comparison with benzydamine in head and neck cancer patients undergoing radiotherapy with or without chemotherapy.

Materials and methods: Phase III randomized clinical trial was conducted from January 2021 till August 2022 on one hundred patients with head and neck cancer receiving high doses of radiotherapy. These patients were equally allocated into either rebamipide group or benzydamine group, The measured outcomes were the incidence of oral mucositis ≥ grade1, according to the WHO mucositis scale, in addition to the duration, and the onset of oral mucositis.

Results: There was no statistically significant difference between the two groups, regarding the incidence of a severe grade of oral mucositis (WHO grades 3), as well as the onset and duration of oral mucositis. Both gargles succeeded to prevent the development of WHO grade 4 oral mucositis. Side effects reported were mainly burning sensation in benzydamine group and nausea in rebamipide group.

Conclusion: Rebamipide mouthwash was as beneficial as benzydamine mouthwash in minimizing the incidence of severe oral mucositis induced by treatment of head and neck cancer. However, rebamipide gargle proved to be superior to benzydamine in terms of reduction in the severity of the radiation-induced oral mucositis.

Trial registration: The trial was registered in the protocol Registration and Result system of Clinical Trials (Registration ID: NCT04685395)0.28-12-2020.

Keywords: Benzydamine HCl; Chemoradiotherapy; Head & neck cancer; Oral mucositis; Radiotherapy; Rebamipide.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flow chart of participants enrollment and analysis
Fig. 2
Fig. 2
Bar chart showing the incidence of oral mucositis in participants who received radiotherapy with or without chemotherapy
Fig. 3
Fig. 3
Bar chart showing a maximum grade of oral mucositis among the participants who received radiotherapy with or without chemotherapy
See this image and copyright information in PMC

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