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Review
. 2024 Feb;202(1):5-16.
doi: 10.1007/s00408-023-00666-y. Epub 2023 Dec 21.

The Therapeutic Landscape in Chronic Cough

Jaclyn A Smith  1   2
Affiliations
Review

The Therapeutic Landscape in Chronic Cough

Jaclyn A Smith. Lung. 2024 Feb.

Abstract

In recent years, there has been a substantial increase in the development of antitussive therapies and the first new therapy, gefapixant has been licenced in Europe. This review describes current unlicenced treatments for chronic cough and details treatments currently in development for refractory chronic cough and cough in idiopathic pulmonary fibrosis, as well as compounds previously explored.

Keywords: Antitussives; Idiopathic pulmonary fibrosis; P2X3 antagonists; Refractory chronic cough.

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Conflict of interest statement

JAS has received consultancy fees from Axalbion, Algernon, AstraZeneca, Bayer, Bellus Health, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Merck, Nocion Therapeutics, Shionogi, and Trevi Therapeutics. The VitaloJAK algorithm has been licenced by Manchester University Foundation Trust (MFT) and the University of Manchester to Vitalograph Ltd and Vitalograph Ireland. MFT receives royalties which may be shared with the clinical division in which JAS works.

Figures

Fig. 1
Fig. 1
Clinical pathways of patients requiring cough treatments; COPD chronic obstructive pulmonary disease, IPF idiopathic pulmonary fibrosis
Fig. 2
Fig. 2
Mechanisms of action of antitussive therapies
Fig. 3
Fig. 3
Current antitussive pipeline 2023. RCC refractory chronic cough, IPF idiopathic pulmonary fibrosis, NaV voltage-gated sodium channel, TRPM8 transient receptor vanilloid potential melastatin 8, OR opioid receptor, NK-1 neurokinin-1, NMDA N-methyl-d-aspartate
See this image and copyright information in PMC

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