This is a preprint.
Bumetanide Exposure Association with Alzheimer's Disease Risk
- PMID: 36909637
- PMCID: PMC10002844
- DOI: 10.21203/rs.3.rs-2574215/v1
Bumetanide Exposure Association with Alzheimer's Disease Risk
Update in
-
Loop diuretics association with Alzheimer's disease risk.Front Aging. 2023 Sep 25;4:1211571. doi: 10.3389/fragi.2023.1211571. eCollection 2023. Front Aging. 2023. PMID: 37822457 Free PMC article.
Abstract
Background: To investigate whether exposure history to two common loop diuretics affects the risk of developing Alzheimer's disease (AD) after accounting for socioeconomic status and congestive heart failure.
Methods: Individuals exposed to bumetanide or furosemide were identified in the Stanford University electronic health record using the deidentified Observational Medical Outcomes Partnership platform. We matched the AD case cohort to a control cohort (1:20 case:control) on gender, race, ethnicity, hypertension and controlled for variables that could potentially be collinear with bumetanide exposure and/or AD diagnosis. Among individuals older than 65 years, 5,839 AD cases and 116,103 matched controls were included. A total of 1,759 patients (54 cases, 1,705 controls) were exposed to bumetanide.
Results: After adjusting for socioeconomic status and other confounders, bumetanide exposure was significantly associated with reduced AD risk (odds ratio = 0.50; 95% confidence interval, 0.37-0.68; p = 9.9×10-6), while the most common loop diuretics, furosemide, was not associated with AD risk.
Conclusion: Our study replicates in an independent sample that history of bumetanide exposure is associated with reduced risk of AD and emphasizes that this association is not confounded by difference in socioeconomic status, which was an important caveat given the cost difference between bumetanide and furosemide.
Keywords: Alzheimer’s disease; bumetanide; electronic health record informatics; furosemide.
Conflict of interest statement
Competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Similar articles
-
Loop diuretics association with Alzheimer's disease risk.Front Aging. 2023 Sep 25;4:1211571. doi: 10.3389/fragi.2023.1211571. eCollection 2023. Front Aging. 2023. PMID: 37822457 Free PMC article.
-
Comparative effectiveness of loop diuretics on mortality in the treatment of patients with chronic heart failure - A multicenter propensity score matched analysis.Int J Cardiol. 2019 Aug 15;289:83-90. doi: 10.1016/j.ijcard.2019.01.109. Epub 2019 Feb 2. Int J Cardiol. 2019. PMID: 30827731
-
Evaluation of Severe Myalgia Induced by Continuous-Infusion Bumetanide in Patients with Acute Heart Failure.Pharmacotherapy. 2019 Aug;39(8):854-860. doi: 10.1002/phar.2297. Epub 2019 Jul 11. Pharmacotherapy. 2019. PMID: 31225921
-
Evaluation of bumetanide as a potential therapeutic agent for Alzheimer's disease.Front Pharmacol. 2023 Aug 4;14:1190402. doi: 10.3389/fphar.2023.1190402. eCollection 2023. Front Pharmacol. 2023. PMID: 37601062 Free PMC article. Review.
-
A comprehensive review of the loop diuretics: should furosemide be first line?Ann Pharmacother. 2009 Nov;43(11):1836-47. doi: 10.1345/aph.1M177. Epub 2009 Oct 20. Ann Pharmacother. 2009. PMID: 19843838 Review.
References
-
- Shah NH, Milstein A, Bagley PhD SC. Making Machine Learning Models Clinically Useful. JAMA. United States; 2019;322:1351–1352. - PubMed
-
- Rajkomar A, Dean J, Kohane I. Machine Learning in Medicine. The New England journal of medicine. United States; 2019;380:1347–1358. - PubMed
-
- Datta S, Posada J, Olson G, et al. A new paradigm for accelerating clinical data science at Stanford Medicine. Epub 2020.
Publication types
Grants and funding
LinkOut - more resources
Full Text Sources