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. 2023 Mar;64(3):426-436.
doi: 10.1111/jcpp.13721. Epub 2022 Nov 4.

Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways

Jessica P Uy  1 , Ai Peng Tan  2 , Birit B F P Broeckman  2 , Peter D Gluckman  2   3 , Yap Seng Chong  2   4   5 , Helen Chen  6 , Marielle V Fortier  2 , Michael J Meaney  2   3   7 , Bridget L Callaghan  1
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Effects of maternal childhood trauma on child emotional health: maternal mental health and frontoamygdala pathways

Jessica P Uy et al. J Child Psychol Psychiatry. 2023 Mar.

Abstract

Background: Experiences of early life adversity pose significant psychological and physical health risks to exposed individuals. Emerging evidence suggests that these health risks can be transmitted across generations; however, the mechanisms underlying the intergenerational impacts of maternal early-life trauma on child health remain unknown.

Methods: The current study used a prospective longitudinal design to determine the unique and joint contributions of maternal childhood trauma (neglect and abuse) and maternal prenatal and postnatal mental health (anxiety and depressive symptoms) (N = 541) to children's resting frontoamygdala functional connectivity at 6 years (N = 89) and emotional health at 7-8 years, as indexed by parent-reported internalizing problems and child self-reported anxiety and depressive symptoms (N = 268-418).

Results: Greater maternal childhood neglect was indirectly associated with greater internalizing problems serially through a pathway of worse maternal prenatal and postnatal mental health (greater maternal anxiety and depressive symptoms). Worse maternal postnatal mental health was also uniquely associated with more negative child frontoamygdala resting-state functional connectivity, over and above maternal childhood trauma (both neglect and abuse) and prenatal mental health. More negative frontoamygdala functional connectivity was, in turn, associated with poorer child emotional health outcomes.

Conclusions: Findings from the current study provide support for the existence of intergenerational influences of parental exposure to childhood trauma on childhood risk for psychopathology in the next generation and point to the importance of maternal factors proximal to the second generation (maternal prenatal and postnatal mental health) in determining the intergenerational impact of maternal early experiences.

Keywords: Maternal childhood trauma; child emotional health; frontoamygdala functional connectivity; maternal depression and anxiety; resting-state fMRI.

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References

    1. Achenbach, T.M., & Rescorla, L.A. (2001). Manual for the ASEBA school-age forms & profiles. Burlington: University of Vermont, Research Center for Children, Youth, & Families.
    1. Ainsworth, M.D.S., & Bell, S.M. (1970). Attachment, exploration, and separation: Illustrated by the behavior of one-year-olds in a strange situation author (s): Mary D. Salter Ainsworth and Silvia M. Bell published by: Wiley on behalf of the Society for Research in child development Sta. Child Development, 41, 49-67.
    1. Bernstein, D.P., Stein, J.A., Newcomb, M.D., Walker, E., Pogge, D., Ahluvalia, T., … & Zule, W. (2003). Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse and Neglect, 27, 169-190.
    1. Bouvette-Turcot, A.A., Fleming, A.S., Unternaehrer, E., Gonzalez, A., Atkinson, L., Gaudreau, H., … & Meaney, M.J. (2020). Maternal symptoms of depression and sensitivity mediate the relation between maternal history of early adversity and her child temperament: The inheritance of circumstance. Development and Psychopathology, 32, 605-613.
    1. Callaghan, B.L., Gee, D.G., Gabard-Durnam, L., Telzer, E.H., Humphreys, K.L., Goff, B., … & Tottenham, N. (2019). Decreased amygdala reactivity to parent cues protects against anxiety following early adversity: An examination across 3 years. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4, 664-671.

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