Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan 6;51(D1):D1003-D1009.
doi: 10.1093/nar/gkac888.

Genenames.org: the HGNC resources in 2023

Ruth L Seal  1   2 , Bryony Braschi  1 , Kristian Gray  1   2 , Tamsin E M Jones  1 , Susan Tweedie  1 , Liora Haim-Vilmovsky  1 , Elspeth A Bruford  1   2
Affiliations

Genenames.org: the HGNC resources in 2023

Ruth L Seal et al. Nucleic Acids Res. .

Abstract

The HUGO Gene Nomenclature Committee (HGNC) assigns unique symbols and names to human genes. The HGNC database (www.genenames.org) currently contains over 43 000 approved gene symbols, over 19 200 of which are assigned to protein-coding genes, 14 000 to pseudogenes and nearly 9000 to non-coding RNA genes. The public website, www.genenames.org, displays all approved nomenclature within Symbol Reports that contain data curated by HGNC nomenclature advisors and links to related genomic, clinical, and proteomic information. Here, we describe updates to our resource, including improvements to our search facility and new download features.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
An example Symbol Report from www.genenames.org. New links to MANE Select, AlphaFold and GenCC are highlighted in red. The symbol AADAC has been marked by HGNC curators with the Stable symbol tag, meaning that the HGNC considers it unlikely that this symbol will ever need to change. The HGNC data box at the top of the Report presents HGNC-curated nomenclature, HGNC ID, chromosomal location and membership of gene groups. The rest of the Symbol Report displays links to biomedical resources, orthology resources and key references.
Figure 2.
Figure 2.
Gene group hierarchy for HGNC curated methyltransferase families. Users can navigate between gene groups by clicking on the gene group boxes.
Figure 3.
Figure 3.
The new auto-suggest feature on the main search at www.genenames.org. The auto-suggest box is scrollable—this query also provides alias symbol suggestions, gene name suggestions and group name suggestions.
See this image and copyright information in PMC

Similar articles

  • Genenames.org: the HGNC and VGNC resources in 2017.
    Yates B, Braschi B, Gray KA, Seal RL, Tweedie S, Bruford EA. Yates B, et al. Nucleic Acids Res. 2017 Jan 4;45(D1):D619-D625. doi: 10.1093/nar/gkw1033. Epub 2016 Oct 30. Nucleic Acids Res. 2017. PMID: 27799471 Free PMC article.
  • A review of the new HGNC gene family resource.
    Gray KA, Seal RL, Tweedie S, Wright MW, Bruford EA. Gray KA, et al. Hum Genomics. 2016 Feb 3;10:6. doi: 10.1186/s40246-016-0062-6. Hum Genomics. 2016. PMID: 26842383 Free PMC article. Review.
  • Gene family matters: expanding the HGNC resource.
    Daugherty LC, Seal RL, Wright MW, Bruford EA. Daugherty LC, et al. Hum Genomics. 2012 Jul 5;6(1):4. doi: 10.1186/1479-7364-6-4. Hum Genomics. 2012. PMID: 23245209 Free PMC article. Review.
  • Genenames.org: the HGNC resources in 2013.
    Gray KA, Daugherty LC, Gordon SM, Seal RL, Wright MW, Bruford EA. Gray KA, et al. Nucleic Acids Res. 2013 Jan;41(Database issue):D545-52. doi: 10.1093/nar/gks1066. Epub 2012 Nov 17. Nucleic Acids Res. 2013. PMID: 23161694 Free PMC article.
  • genenames.org: the HGNC resources in 2011.
    Seal RL, Gordon SM, Lush MJ, Wright MW, Bruford EA. Seal RL, et al. Nucleic Acids Res. 2011 Jan;39(Database issue):D514-9. doi: 10.1093/nar/gkq892. Epub 2010 Oct 6. Nucleic Acids Res. 2011. PMID: 20929869 Free PMC article.
See all similar articles

Cited by

See all "Cited by" articles

References

    1. Hancock J.M., Game A., Ponting C.P., Goble C.A.. An open and transparent process to select ELIXIR node services as implemented by ELIXIR-UK. F1000Res. 2016; 5:2894. - PMC - PubMed
    1. Sansone S.A., McQuilton P., Rocca-Serra P., Gonzalez-Beltran A., Izzo M., Lister A.L., Thurston M., Community F.. FAIRsharing as a community approach to standards, repositories and policies. Nat. Biotechnol. 2019; 37:358–367. - PMC - PubMed
    1. Braschi B., Seal R.L., Tweedie S., Jones T.E.M., Bruford E.A.. The risks of using unapproved gene symbols. Am. J. Hum. Genet. 2021; 108:1813–1816. - PMC - PubMed
    1. Seal R.L., Tweedie S., Bruford E.A.. A standardised nomenclature for long non-coding RNAs. IUBMB Life. 2022; 10.1002/iub.2663. - DOI - PubMed
    1. Sayers E.W., Beck J., Bolton E.E., Bourexis D., Brister J.R., Canese K., Comeau D.C., Funk K., Kim S., Klimke W.et al. .. Database resources of the national center for biotechnology information. Nucleic Acids Res. 2021; 49:D10–D17. - PMC - PubMed

Publication types

LinkOut - more resources