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. 2021 Nov 1;78(11):1407-1409.
doi: 10.1001/jamaneurol.2021.2823.

Plasma Biomarkers of Tau and Neurodegeneration During Major Cardiac and Noncardiac Surgery

Igor Feinstein  1 , Edward N Wilson  2 , Michelle S Swarovski  2 , Katrin I Andreasson  2 , Martin S Angst  1 , Michael D Greicius  2
Affiliations

Plasma Biomarkers of Tau and Neurodegeneration During Major Cardiac and Noncardiac Surgery

Igor Feinstein et al. JAMA Neurol. .

Abstract

This analysis compares plasma biomarkers of tau and neurodegeneration during major cardiac and noncardiac surgeries.

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Conflict of interest statement

Conflict of Interest Disclosures: None were reported.

Figures

Figure.
Figure.. pTau181 and Neurofilament Light Chain (NfL) Plasma Concentrations Increase Significantly During the Perioperative Period
A, In patients undergoing cardiac surgery, pTau181 concentrations peak during surgery and remain elevated on postoperative days 1 (POD1) and 2 (POD2). Lines are color coded to distinguish individual patients. B, A similar but less pronounced temporal pattern was observed in patients undergoing hip replacement surgery. C, In patients undergoing cardiac surgery, NfL levels remain flat on the day of surgery, but peak on POD1 and POD2. D, In contrast, no significant elevation of NfL was detected in patients undergoing hip replacement surgery. Data are analyzed by repeated-measures analysis of variance with Tukey post hoc multiple comparisons test. CPB indicates cardiopulmonary bypass. aP < .05. bP < .01. cP < .001.
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