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. 2020 Dec 24;383(26):2586-2588.
doi: 10.1056/NEJMc2031670. Epub 2020 Dec 1.

Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer

Teresa Aydillo  1 , Ana S Gonzalez-Reiche  1 , Sadaf Aslam  1 , Adriana van de Guchte  1 , Zenab Khan  1 , Ajay Obla  1 , Jayeeta Dutta  1 , Harm van Bakel  1 , Judith Aberg  1 , Adolfo García-Sastre  1 , Gunjan Shah  2 , Tobias Hohl  2 , Genovefa Papanicolaou  2 , Miguel-Angel Perales  2 , Kent Sepkowitz  2 , N Esther Babady  2 , Mini Kamboj  2
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Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer

Teresa Aydillo et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Study Design and Genetic Variant Profiles of Sequenced SARS-CoV-2.
Panel A shows the patient enrollment, respiratory sample collection (all nasopharyngeal samples except for one sputum sample), and testing design. The 𝙸 bar indicates serial collection of samples. RT-qPCR denotes quantitative reverse-transcriptase polymerase chain reaction. Panel B shows the genetic variant profiles of sequenced SARS-CoV-2 relative to the Wuhan-Hu-1 reference genome in 13 patients who had at least one cultured isolate (plus sign), more than one longitudinal sample sequenced, or both. The genomes shown were derived from the original respiratory samples. The mean (±SD) read depth was 2481±1558 reads per base. Assembled genomic regions are indicated by shaded areas colored according to patient, and gaps in coverage are indicated by white areas. Complete genome sequences from the 4 patients who did not have a corresponding culture or follow-up samples are not included. The replicase domains (ORF1ab 1 and 2, ORF3a, ORF6, ORF7a, and ORF8) and the S, M, and N regions of the reference genome are shown on the x axis. UTR denotes untranslated region.
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References

    1. Arons MM, Hatfield KM, Reddy SC, et al. Presymptomatic SARS-CoV-2 infections and transmission in a skilled nursing facility. N Engl J Med 2020;382:2081-2090. - PMC - PubMed
    1. Centers for Disease Control and Prevention. Discontinuation of transmission-based precautions and disposition of patients with COVID-19 in healthcare settings (interim guidance). August 10, 2020. (https://www.cdc.gov/coronavirus/2019-ncov/hcp/disposition-hospitalized-p...).

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