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Review
. 2018 Jul 11;99(1):13-27.
doi: 10.1016/j.neuron.2018.06.003.

Dendritic Tau in Alzheimer's Disease

Arne Ittner  1 , Lars M Ittner  2
Affiliations
Free article
Review

Dendritic Tau in Alzheimer's Disease

Arne Ittner et al. Neuron. .
Free article

Abstract

The microtubule-associated protein tau and amyloid-β (Aβ) are key players in Alzheimer's disease (AD). Aβ and tau are linked in a molecular pathway at the post-synapse with tau-dependent synaptic dysfunction being a major pathomechanism in AD. Recent work on site-specific modification of dendritic and more specifically post-synaptic tau has revealed new endogenous functions of tau that limits synaptic Aβ toxicity. Thus, molecular studies opened a new perspective on tau, placing it at the center of neurotoxic and neuroprotective signaling at the post-synapse. Here, we review recent advances on tau in the dendritic compartments, with implications for understanding and treatment of AD and related neurological conditions.

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