Mosquito-borne viral diseases and potential transmission blocking vaccine candidates
- PMID: 29842982
- DOI: 10.1016/j.meegid.2018.05.023
Mosquito-borne viral diseases and potential transmission blocking vaccine candidates
Abstract
Mosquito-borne viral diseases (MBVDs) have a complex biological cycle involving vectors and vertebrate hosts. These viruses are responsible for many deadly diseases worldwide. Although MBVDs threaten mostly developing countries, there is growing evidence indicating that they are also of concern in western countries where local transmission of arboviruses such as West Nile, Zika, Chikungunya and Dengue viruses have been recently reported. The rapid rise in human infections caused by these viruses is attributed to rapid climate change and travel facilities. Usually, the only way to control these diseases relies on the control of vectors in the absence of licensed vaccines and specific treatments. However, the overuse of insecticides has led to the emergence of insecticide resistance in vector populations, posing significant challenges for their control. An alternative method for reducing MBVDs can be the use of Transmission Blocking Vaccines (TBVs) that limits viral infection at the mosquito vector stage. Some successes have been obtained confirming the potential application of TBVs against viruses; however, this approach remains at the developmental stage and still needs improvements. The present review aims to give an update on MBVDs and to discuss the application as well as usage of potential TBVs for the control of mosquito-borne viral infections.
Keywords: Flaviviruses; Mosquito-borne viral diseases; Transmission blocking vaccine.
Copyright © 2018. Published by Elsevier B.V.
Similar articles
-
Antiviral Compounds for Blocking Arboviral Transmission in Mosquitoes.Viruses. 2021 Jan 14;13(1):108. doi: 10.3390/v13010108. Viruses. 2021. PMID: 33466915 Free PMC article. Review.
-
Alternative strategies for mosquito-borne arbovirus control.PLoS Negl Trop Dis. 2019 Jan 3;13(1):e0006822. doi: 10.1371/journal.pntd.0006822. eCollection 2019 Jan. PLoS Negl Trop Dis. 2019. PMID: 30605475 Free PMC article. Review.
-
Mosquito Saliva: The Hope for a Universal Arbovirus Vaccine?J Infect Dis. 2018 Jun 5;218(1):7-15. doi: 10.1093/infdis/jiy179. J Infect Dis. 2018. PMID: 29617849 Free PMC article. Review.
-
From dengue to Zika: the wide spread of mosquito-borne arboviruses.Eur J Clin Microbiol Infect Dis. 2019 Jan;38(1):3-14. doi: 10.1007/s10096-018-3375-7. Epub 2018 Sep 28. Eur J Clin Microbiol Infect Dis. 2019. PMID: 30267170 Review.
-
Genetic Determinants of the Re-Emergence of Arboviral Diseases.Viruses. 2019 Feb 12;11(2):150. doi: 10.3390/v11020150. Viruses. 2019. PMID: 30759739 Free PMC article. Review.
Cited by
-
Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses.Hum Vaccin Immunother. 2022 Nov 30;18(5):2079323. doi: 10.1080/21645515.2022.2079323. Epub 2022 Jun 17. Hum Vaccin Immunother. 2022. PMID: 35714271 Free PMC article. Review.
-
Vertebrate Responses against Arthropod Salivary Proteins and Their Therapeutic Potential.Vaccines (Basel). 2021 Apr 5;9(4):347. doi: 10.3390/vaccines9040347. Vaccines (Basel). 2021. PMID: 33916367 Free PMC article. Review.
-
The worldwide seroprevalence of DENV, CHIKV and ZIKV infection: A systematic review and meta-analysis.PLoS Negl Trop Dis. 2021 Apr 28;15(4):e0009337. doi: 10.1371/journal.pntd.0009337. eCollection 2021 Apr. PLoS Negl Trop Dis. 2021. PMID: 33909610 Free PMC article.
-
Developing a Vaccine to Block West Nile Virus Transmission: In Silico Studies, Molecular Characterization, Expression, and Blocking Activity of Culex pipiens mosGCTL-1.Pathogens. 2021 Feb 17;10(2):218. doi: 10.3390/pathogens10020218. Pathogens. 2021. PMID: 33671430 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
