Maturation of the gut microbiome and risk of asthma in childhood
- PMID: 29321519
- PMCID: PMC5762761
- DOI: 10.1038/s41467-017-02573-2
Maturation of the gut microbiome and risk of asthma in childhood
Erratum in
-
Publisher Correction: Maturation of the gut microbiome and risk of asthma in childhood.Nat Commun. 2018 Feb 13;9(1):704. doi: 10.1038/s41467-018-03150-x. Nat Commun. 2018. PMID: 29440648 Free PMC article.
Abstract
The composition of the human gut microbiome matures within the first years of life. It has been hypothesized that microbial compositions in this period can cause immune dysregulations and potentially cause asthma. Here we show, by associating gut microbial composition from 16S rRNA gene amplicon sequencing during the first year of life with subsequent risk of asthma in 690 participants, that 1-year-old children with an immature microbial composition have an increased risk of asthma at age 5 years. This association is only apparent among children born to asthmatic mothers, suggesting that lacking microbial stimulation during the first year of life can trigger their inherited asthma risk. Conversely, adequate maturation of the gut microbiome in this period may protect these pre-disposed children.
Conflict of interest statement
MJB discloses his participation on the Scientific Advisory Board of Commense, Inc. The other authors declare no competing financial interests.
Figures
![Fig. 1](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5762761/bin/41467_2017_2573_Fig1_HTML.gif)
![Fig. 2](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5762761/bin/41467_2017_2573_Fig2_HTML.gif)
![Fig. 3](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5762761/bin/41467_2017_2573_Fig3_HTML.gif)
![Fig. 4](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5762761/bin/41467_2017_2573_Fig4_HTML.gif)
![Fig. 5](https://cdn.statically.io/img/www.ncbi.nlm.nih.gov/pmc/articles/instance/5762761/bin/41467_2017_2573_Fig5_HTML.gif)
Similar articles
-
Environmental and genetic associations with aberrant early-life gut microbial maturation in childhood asthma.J Allergy Clin Immunol. 2023 Jun;151(6):1494-1502.e14. doi: 10.1016/j.jaci.2023.01.006. Epub 2023 Jan 14. J Allergy Clin Immunol. 2023. PMID: 36649759 Free PMC article.
-
Host-microbiome intestinal interactions during early life: considerations for atopy and asthma development.Curr Opin Allergy Clin Immunol. 2020 Apr;20(2):138-148. doi: 10.1097/ACI.0000000000000629. Curr Opin Allergy Clin Immunol. 2020. PMID: 32004178 Review.
-
Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner.Microbiome. 2018 Jul 5;6(1):109. doi: 10.1186/s40168-018-0490-8. Microbiome. 2018. PMID: 29973274 Free PMC article.
-
The Neonatal Microbiome and Its Partial Role in Mediating the Association between Birth by Cesarean Section and Adverse Pediatric Outcomes.Neonatology. 2018;114(2):103-111. doi: 10.1159/000487102. Epub 2018 May 22. Neonatology. 2018. PMID: 29788027 Free PMC article. Review.
-
Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation.Nat Med. 2016 Oct;22(10):1187-1191. doi: 10.1038/nm.4176. Epub 2016 Sep 12. Nat Med. 2016. PMID: 27618652 Free PMC article.
Cited by
-
Probiotics in the New Era of Human Milk Oligosaccharides (HMOs): HMO Utilization and Beneficial Effects of Bifidobacterium longum subsp. infantis M-63 on Infant Health.Microorganisms. 2024 May 17;12(5):1014. doi: 10.3390/microorganisms12051014. Microorganisms. 2024. PMID: 38792843 Free PMC article. Review.
-
Missing microbes in infants and children in the COVID-19 pandemic: a study of 1,126 participants in Beijing, China.Sci China Life Sci. 2024 May 9. doi: 10.1007/s11427-023-2488-0. Online ahead of print. Sci China Life Sci. 2024. PMID: 38748355
-
Veillonella and Bacteroides are associated with gestational diabetes mellitus exposure and gut microbiota immaturity.PLoS One. 2024 May 14;19(5):e0302726. doi: 10.1371/journal.pone.0302726. eCollection 2024. PLoS One. 2024. PMID: 38743706 Free PMC article.
-
Analysis of the characteristics of intestinal microbiota after oral tolerance in infants with food protein-induced proctocolitis.Front Pediatr. 2024 Apr 26;12:1338294. doi: 10.3389/fped.2024.1338294. eCollection 2024. Front Pediatr. 2024. PMID: 38737636 Free PMC article.
-
Co-localization of antibiotic resistance genes is widespread in the infant gut microbiome and associates with an immature gut microbial composition.Microbiome. 2024 May 10;12(1):87. doi: 10.1186/s40168-024-01800-5. Microbiome. 2024. PMID: 38730321 Free PMC article.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical