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. 2015 Oct;36(10):2678-86.
doi: 10.1016/j.neurobiolaging.2015.06.029. Epub 2015 Jul 16.

Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants

Manja Lehmann  1 , Cindee Madison  2 , Pia M Ghosh  3 , Zachary A Miller  4 , Michael D Greicius  5 , Joel H Kramer  4 , Giovanni Coppola  6 , Bruce L Miller  4 , William J Jagust  7 , Maria L Gorno-Tempini  4 , William W Seeley  4 , Gil D Rabinovici  7
Affiliations

Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants

Manja Lehmann et al. Neurobiol Aging. 2015 Oct.

Abstract

The common and specific involvement of brain networks in clinical variants of Alzheimer's disease (AD) is not well understood. We performed task-free ("resting-state") functional imaging in 60 nonfamilial AD patients, including 20 early-onset AD (age at onset <65 years, amnestic/dysexecutive deficits), 24 logopenic aphasia (language deficits), and 16 posterior cortical atrophy patients (visual deficits), as well as 60 healthy controls. Seed-based connectivity analyses were conducted to assess differences between groups in 3 default mode network (DMN) components (anterior, posterior, and ventral) and 4 additional non-DMN networks: left and right executive-control, language, and higher visual networks. Significant decreases in connectivity were found across AD variants compared with controls in the non-DMN networks. Within the DMN components, patients showed higher connectivity in the anterior DMN, in particular in logopenic aphasia. No significant differences were found for the posterior and ventral DMN. Our findings suggest that loss of functional connectivity is greatest in networks outside the DMN in early-onset and nonamnestic AD variants and may thus be a better biomarker in these patients.

Keywords: Alzheimer's disease; Functional magnetic resonance imaging; Intrinsic connectivity; Logopenic-variant primary progressive aphasia; Networks; Posterior cortical atrophy.

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Figures

Figure 1
Figure 1
Connectivity z-scores for different networks in each group and p values for group comparisons. Means and standard deviations for each group are shown at the bottom of each graph.
Figure 2
Figure 2
Differences in connectivity in patients compared with controls in anterior, posterior and ventral DMN components. Shown are p-maps (p<0.05 uncorrected) with red indicating lower connectivity in the patients, whereas blue indicates higher connectivity compared with controls.
Figure 3
Figure 3
Differences in connectivity in patients compared with controls in left and right executive-control, language and higher visual networks. Shown are p-maps (p<0.05 uncorrected) with red indicating lower connectivity in the patients, whereas blue indicates higher connectivity compared with controls.
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