Consumption of sucrose and high-fructose corn syrup does not increase liver fat or ectopic fat deposition in muscles
- PMID: 23724887
- DOI: 10.1139/apnm-2012-0322
Consumption of sucrose and high-fructose corn syrup does not increase liver fat or ectopic fat deposition in muscles
Abstract
It has been postulated that fructose-induced triglyceride synthesis is augmented when accompanied by glucose. Chronic elevations could lead to excess fat accumulation in the liver and ectopic fat deposition in muscles, which in turn could contribute to the induction of abnormalities in glucose homeostasis, insulin resistance, and the subsequent development of type 2 diabetes. Our objective was to evaluate the effect of the addition of commonly consumed fructose- and (or) glucose-containing sugars in the usual diet on liver fat content and intramuscular adipose tissue. For 10 weeks, 64 individuals (mean age, 42.16 ± 11.66 years) consumed low-fat milk sweetened with either high-fructose corn syrup (HFCS) or sucrose; the added sugar matched consumption levels of fructose in the 25th, 50th, and 90th percentiles of the population. The fat content of the liver was measured with unenhanced computed tomography imaging, and the fat content of muscle was assessed with magnetic resonance imaging. When the 6 HFCS and sucrose groups were averaged, there was no change over the course of 10 weeks in the fat content of the liver (13.32% ± 10.49% vs. 13.21% ± 10.75%; p > 0.05), vastus lateralis muscle (3.07 ± 0.74 g per 100 mL vs. 3.15 ± 0.84 g per 100 mL; p > 0.05), or gluteus maximus muscle (4.08 ± 1.50 g per 100 mL vs. 4.24 ± 1.42 g per 100 mL; p > 0.05). Group assignment did not affect the result (interaction > 0.05). These data suggest that when fructose is consumed as part of a typical diet in normally consumed sweeteners, such as sucrose or HFCS, ectopic fat storage in the liver or muscles is not promoted.
Similar articles
-
High-fructose corn syrup and sucrose have equivalent effects on energy-regulating hormones at normal human consumption levels.Nutr Res. 2013 Dec;33(12):1043-52. doi: 10.1016/j.nutres.2013.07.020. Epub 2013 Aug 30. Nutr Res. 2013. PMID: 24267044 Clinical Trial.
-
Impact of perinatal exposure to sucrose or high fructose corn syrup (HFCS-55) on adiposity and hepatic lipid composition in rat offspring.J Physiol. 2017 Jul 1;595(13):4379-4398. doi: 10.1113/JP274066. Epub 2017 May 26. J Physiol. 2017. PMID: 28447343 Free PMC article.
-
Fructose content in popular beverages made with and without high-fructose corn syrup.Nutrition. 2014 Jul-Aug;30(7-8):928-35. doi: 10.1016/j.nut.2014.04.003. Epub 2014 Apr 18. Nutrition. 2014. PMID: 24985013
-
Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people.Adv Nutr. 2013 Mar 1;4(2):220-5. doi: 10.3945/an.112.002816. Adv Nutr. 2013. PMID: 23493538 Free PMC article. Review.
-
Sugar consumption, metabolic disease and obesity: The state of the controversy.Crit Rev Clin Lab Sci. 2016;53(1):52-67. doi: 10.3109/10408363.2015.1084990. Epub 2015 Sep 17. Crit Rev Clin Lab Sci. 2016. PMID: 26376619 Free PMC article. Review.
Cited by
-
Differential Effect of Fructose in the Presence or Absence of Fatty Acids on Circadian Metabolism in Hepatocytes.Metabolites. 2023 Jan 17;13(2):138. doi: 10.3390/metabo13020138. Metabolites. 2023. PMID: 36837757 Free PMC article.
-
Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome.Cell. 2022 Sep 15;185(19):3501-3519.e20. doi: 10.1016/j.cell.2022.08.005. Epub 2022 Aug 29. Cell. 2022. PMID: 36041436 Free PMC article.
-
Towards defining muscular regions of interest from axial magnetic resonance imaging with anatomical cross-reference: a scoping review of lateral hip musculature.BMC Musculoskelet Disord. 2022 Jun 4;23(1):533. doi: 10.1186/s12891-022-05439-x. BMC Musculoskelet Disord. 2022. PMID: 35658932 Free PMC article. Review.
-
The Dose-Response Effects of Consuming High Fructose Corn Syrup-Sweetened Beverages on Hepatic Lipid Content and Insulin Sensitivity in Young Adults.Nutrients. 2022 Apr 15;14(8):1648. doi: 10.3390/nu14081648. Nutrients. 2022. PMID: 35458210 Free PMC article.
-
Current WHO recommendation to reduce free sugar intake from all sources to below 10% of daily energy intake for supporting overall health is not well supported by available evidence.Am J Clin Nutr. 2022 Jul 6;116(1):15-39. doi: 10.1093/ajcn/nqac084. Am J Clin Nutr. 2022. PMID: 35380611 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources