Decreased daytime motor activity associated with apathy in Alzheimer disease: an actigraphic study
- PMID: 21997602
- DOI: 10.1097/JGP.0b013e31823038af
Decreased daytime motor activity associated with apathy in Alzheimer disease: an actigraphic study
Abstract
Objective: Across all stages of Alzheimer disease (AD), apathy is the most common neuropsychiatric symptom. Studies using the Neuropsychiatric Inventory (NPI) have found that apathy is present in up to 70% of individuals with Alzheimer disease. One of the main difficulties in assessing apathy and other neuropsychiatric symptoms is the absence of reliable, objective measures. Motor activity assessment using ambulatory actigraphy could provide an indirect, objective evaluation of apathy. The aim of our study was to assess the relationship between apathy and daytime motor activity in AD, using ambulatory actigraphy.
Methods: One hundred seven AD outpatients wore a wrist actigraph (Motionlogger) during seven consecutive 24-hour periods to evaluate motor activity. Participants were divided into two subgroups according to their apathy subscores on the NPI: individuals with apathy (NPI-apathy subscores >4) and those without. Daytime mean motor activity scores were compared between the two subgroups.
Results: Individuals with AD who had symptoms of apathy (n = 43; age = 79 ± 4.7 years; Mini-Mental State Examination = 20.9 ± 4.8) had significantly lower daytime mean motor activity than AD patients without apathy (n = 64; age = 76.3 ± 7.7; Mini-Mental State Examination = 21.5 ± 4.7), while nighttime mean motor activity did not significantly differ between the two subgroups.
Conclusions: Ambulatory actigraphy could be added to currently used questionnaires as a simple, objective technique for assessing apathy in the routine assessment of AD patients.
Similar articles
-
Relationship between apathy and sleep disturbance in mild and moderate Alzheimer's disease: an actigraphic study.J Alzheimers Dis. 2011;25(1):85-91. doi: 10.3233/JAD-2011-101701. J Alzheimers Dis. 2011. PMID: 21335662
-
Actigraphic daytime activity is reduced in patients with cognitive impairment and apathy.Eur Psychiatry. 2013 Feb;28(2):94-7. doi: 10.1016/j.eurpsy.2011.04.006. Epub 2011 Jun 21. Eur Psychiatry. 2013. PMID: 21696925
-
Phenotyping apathy in individuals with Alzheimer disease using functional principal component analysis.Am J Geriatr Psychiatry. 2013 Apr;21(4):391-7. doi: 10.1016/j.jagp.2012.12.012. Epub 2013 Feb 6. Am J Geriatr Psychiatry. 2013. PMID: 23498386 Free PMC article.
-
Treating apathy in Alzheimer's disease.Dement Geriatr Cogn Disord. 2004;17(1-2):91-9. doi: 10.1159/000074280. Epub 2003 Oct 15. Dement Geriatr Cogn Disord. 2004. PMID: 14564128 Review.
-
Pharmacological and Nonpharmacological Treatment for Apathy in Alzheimer Disease : A systematic review across modalities.J Geriatr Psychiatry Neurol. 2017 Jan;30(1):26-49. doi: 10.1177/0891988716678684. J Geriatr Psychiatry Neurol. 2017. PMID: 28248559 Review.
Cited by
-
Early Stage Detection of Alzheimer's Disease With Microsoft Azure Based Deep Learning.Res Sq [Preprint]. 2023 Nov 17:rs.3.rs-3352620. doi: 10.21203/rs.3.rs-3352620/v1. Res Sq. 2023. PMID: 38014038 Free PMC article. Preprint.
-
Detection of Alzheimer's Disease Based on Cloud-Based Deep Learning Paradigm.Diagnostics (Basel). 2023 Aug 15;13(16):2687. doi: 10.3390/diagnostics13162687. Diagnostics (Basel). 2023. PMID: 37627946 Free PMC article.
-
An Update on Apathy in Alzheimer's Disease.Geriatrics (Basel). 2023 Jul 14;8(4):75. doi: 10.3390/geriatrics8040075. Geriatrics (Basel). 2023. PMID: 37489323 Free PMC article. Review.
-
Using Digital Technology to Quantify Habitual Physical Activity in Community Dwellers With Cognitive Impairment: Systematic Review.J Med Internet Res. 2023 May 18;25:e44352. doi: 10.2196/44352. J Med Internet Res. 2023. PMID: 37200065 Free PMC article. Review.
-
A scoping review of neurodegenerative manifestations in explainable digital phenotyping.NPJ Parkinsons Dis. 2023 Mar 30;9(1):49. doi: 10.1038/s41531-023-00494-0. NPJ Parkinsons Dis. 2023. PMID: 36997573 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical