Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 May 30;187(3):397-400.
doi: 10.1016/j.psychres.2011.01.007. Epub 2011 Feb 2.

Faster REM sleep EEG and worse restedness in older insomniacs with HLA DQB1*0602

Jamie Marc Zeitzer  1 , Ryan Anthony Fisicaro, Megan Elizabeth Grove, Emmanuel Mignot, Jerome Albert Yesavage, Leah Friedman
Affiliations

Faster REM sleep EEG and worse restedness in older insomniacs with HLA DQB1*0602

Jamie Marc Zeitzer et al. Psychiatry Res. .

Abstract

HLA DQB1*0602 is found in most individuals with hypocretin-deficient narcolepsy, a disorder characterized by a severe disruption of sleep and wake. Population studies indicate that DQB1*0602 may also be associated with normal phenotypic variation of rapid eye movement (REM) sleep. Disruption of REM sleep has been linked to specific symptoms of insomnia. We here examine the relationship of sleep and DQB1*0602 in older individuals (n=46) with primary insomnia, using objective (polysomnography, wrist actigraphy) and subjective (logs, scales) measures. DQB1*0602 positivity was similarly distributed in the older individuals with insomnia (24%) as in the general population (25%). Most sleep variables were statistically indistinguishable between DQB1*0602 positive and negative subjects except that those with the allele reported that they were significantly less well rested than those without it. When sleep efficiencies were lower than 70%, DQB1*0602 positive subjects reported being less well rested at the same sleep efficiency than those without the allele. Examination of EEG during REM sleep also revealed that DQB1*0602 positive subjects had EEG shifted towards faster frequencies compared with negative subjects. Thus, DQB1*0602 positivity is associated with both a shift in EEG power spectrum to faster frequencies during REM sleep and a diminution of restedness given the same sleep quantity.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Subjective restedness by sleep efficiency varies by genotype. Subjective sleep efficiency correlates strongly with subjective restedness after a night of sleep and this relationship varies by the presence (black) or absence (grey) of DQB1*0602 such that below 70%, the relationship is different in the two genotypes. Linear regressions shown with 95% confidence intervals.
Figure 2
Figure 2
Frequency shift in REM sleep varies by genotype. Relative power in individuals with (black) or without (grey) the DQB1*0602 allele varies such that those with the allele have more faster frequencies during REM sleep. Data were averaged over two nights within and then between subjects. Average ± SD is shown. The asterisk indicates significance by t-test at P < 0.00833.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Ancoli-Israel S, Cole R, Alessi C, Chambers M, Moorcroft W, Pollack CP. The role of actigraphy in the study of sleep and circadian rhythms. Sleep. 2003;26:342–392. - PubMed
    1. Bourgin P, Zeitzer JM, Mignot E. CSF hypocretin-1 assessment in sleep and neurological disorders. Lancet Neurology. 2008;7:649–662. - PubMed
    1. España RA, Scammell TE. Sleep neurobiology for the clinician. Sleep. 2004;27:811–820. - PubMed
    1. Feige B, Al-Shajlawi A, Nissen C, Voderholzer U, Hornyak M, Spiegelhalder K, Kloepfer C, Perlis M, Riemann D. Does REM sleep contribute to subjective wake time in primary insomnia? A comparison of polysomnographic and subjective sleep in 100 patients. Journal of Sleep Research. 2008;17:180–190. - PubMed
    1. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research. 1975;12:189–198. - PubMed

Publication types