Levels of hemoglobin and lipid peroxidation metabolites in blood, catalase activity in erythrocytes and peak expiratory flow rate in subjects with passive exposure to tobacco smoke
- PMID: 19202948
Levels of hemoglobin and lipid peroxidation metabolites in blood, catalase activity in erythrocytes and peak expiratory flow rate in subjects with passive exposure to tobacco smoke
Abstract
Introduction: Exposure to tobacco smoke is an extremely important risk factor determining the development of respiratory diseases, cardiovascular diseases and cancer. Passive exposure is common and often not realized by the exposed subjects. Markers of tobacco smoke exposure are nicotine metabolites, i.e. cotinine and trans-3'-hydroxycotinine.
Objectives: The objective of the study was to assess the level of passive exposure to tobacco smoke among students and the exposure impact on the blood hemoglobin level, peak expiratory flow (PEF), lipid peroxidation level and antioxidant enzyme activity.
Patients and methods: A total of 104 subjects were enrolled in the study. The subjects were categorized in 3 subgroups depending on nicotine metabolite levels in blood (subgroup I with metabolite level > 100 ng/ml (high exposure); subgroup II with the metabolite level of 10-100 ng/ml; subgroup III with metabolite level <10 ng/ml). The blood hemoglobin level, PEF, levels of lipid peroxidation metabolites--malondialdehyde and 4-hydroxynonenal (MDA + 4-HNE) and catalase (CAT) activity were determined in all the subjects.
Results: The study showed statistically significant differences in levels of lipid peroxidation metabolites and CAT activity. Levels of MDA + 4-HNE were higher in subgroup I than in subgroup II or III (I: 3.84 +/- 1.64 mmol/l; II: 2.25 +/- 0.94 mmol/l; III: 1.90 +/- 0.82 mmol/l; pI-II < 0.01; pI-III <0.001). CAT activity was statistically significantly lower in subgroup I than in subgroup III (I: 0.38 +/- 0.01 x 10(6) IU/g hemoglobin [Hb]; II: 0.38 +/- 0.03 x 10(6) IU/g Hb; III: 0.41 +/- 0.04 x 10(6) IU/g Hb; pI-III <0.05).
Conclusions: Passive exposure to tobacco smoke in the study population of students is common. The observed effects of passive exposure to tobacco smoke are similar to those of active smoking. It is postulated to undertake actions aiming at limiting passive exposure to tobacco smoke.
Similar articles
-
[Oxidative stress biomarkers determination in urine samples in the group of medical students exposed to tobacco smoke].Przegl Lek. 2010;67(10):920-4. Przegl Lek. 2010. PMID: 21360927 Polish.
-
[Environmental tobacco smoke--assessment of formaldehyde concentration in urine samples of exposed medicine students].Przegl Lek. 2015;72(3):140-3. Przegl Lek. 2015. PMID: 26731871 Polish.
-
[Evaluation of the influence of exposure to tobacco smoke on the concentration of the pregnancy-associated plasma protein A in the population of healthy men and non-pregnant women].Przegl Lek. 2013;70(10):813-7. Przegl Lek. 2013. PMID: 24501802 Polish.
-
[Cotinine--the biomarker of exposure to tobacco smoke].Przegl Lek. 1999;56(2):161-3. Przegl Lek. 1999. PMID: 10375952 Review. Polish.
-
[Biomarkers of tobacco smoke exposure].Ann Biol Clin (Paris). 2002 May-Jun;60(3):263-72. Ann Biol Clin (Paris). 2002. PMID: 12050041 Review. French.
Cited by
-
Assessment of serum cotinine in patients with chronic heart failure: self-reported versus objective smoking behaviour.Clin Res Cardiol. 2013 Feb;102(2):95-101. doi: 10.1007/s00392-012-0499-0. Epub 2012 Aug 10. Clin Res Cardiol. 2013. PMID: 22878732
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous