Exploring the full spectrum of macrophage activation
- PMID: 19029990
- PMCID: PMC2724991
- DOI: 10.1038/nri2448
Exploring the full spectrum of macrophage activation
Erratum in
- Nat Rev Immunol.2010 Jun;10(6):460
Abstract
Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions. In this Review we suggest a new grouping of macrophage populations based on three different homeostatic activities - host defence, wound healing and immune regulation. We propose that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation. We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations.
Figures
Similar articles
-
Macrophage Motility in Wound Healing Is Regulated by HIF-1α via S1P Signaling.Int J Mol Sci. 2021 Aug 20;22(16):8992. doi: 10.3390/ijms22168992. Int J Mol Sci. 2021. PMID: 34445695 Free PMC article. Review.
-
Diversity, Mechanisms, and Significance of Macrophage Plasticity.Annu Rev Pathol. 2020 Jan 24;15:123-147. doi: 10.1146/annurev-pathmechdis-012418-012718. Epub 2019 Sep 17. Annu Rev Pathol. 2020. PMID: 31530089 Free PMC article. Review.
-
Amnion-derived cellular cytokine solution promotes macrophage activity.Ann Plast Surg. 2011 May;66(5):575-80. doi: 10.1097/SAP.0b013e318212f1d0. Ann Plast Surg. 2011. PMID: 21451377
-
From inflammation to wound healing: using a simple model to understand the functional versatility of murine macrophages.Bull Math Biol. 2011 Nov;73(11):2575-604. doi: 10.1007/s11538-011-9637-5. Epub 2011 Feb 23. Bull Math Biol. 2011. PMID: 21347813 Free PMC article.
-
Wound healing: the role of the macrophage and other immune cells.Shock. 1995 Oct;4(4):233-40. Shock. 1995. PMID: 8564549 Review.
Cited by
-
Current and future immunotherapeutic approaches in pancreatic cancer treatment.J Hematol Oncol. 2024 Jun 4;17(1):40. doi: 10.1186/s13045-024-01561-6. J Hematol Oncol. 2024. PMID: 38835055 Free PMC article. Review.
-
Agent-based model demonstrates the impact of nonlinear, complex interactions between cytokinces on muscle regeneration.Elife. 2024 Jun 3;13:RP91924. doi: 10.7554/eLife.91924. Elife. 2024. PMID: 38828844 Free PMC article.
-
Immunoreactive Microenvironment Modulator GBP5 Suppresses Ovarian Cancer Progression by Inducing Canonical Pyroptosis.J Cancer. 2024 May 5;15(11):3510-3530. doi: 10.7150/jca.94616. eCollection 2024. J Cancer. 2024. PMID: 38817865 Free PMC article.
-
Multi-omics analysis of macrophage-associated receptor and ligand reveals a strong prognostic signature and subtypes in hepatocellular carcinoma.Sci Rep. 2024 May 28;14(1):12163. doi: 10.1038/s41598-024-62668-x. Sci Rep. 2024. PMID: 38806553 Free PMC article.
-
Anti-ferroptosis exosomes engineered for targeting M2 microglia to improve neurological function in ischemic stroke.J Nanobiotechnology. 2024 May 27;22(1):291. doi: 10.1186/s12951-024-02560-y. J Nanobiotechnology. 2024. PMID: 38802919 Free PMC article.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources