Brain morphometry volume in autistic spectrum disorder: a magnetic resonance imaging study of adults
- PMID: 18775096
- DOI: 10.1017/S0033291708003383
Brain morphometry volume in autistic spectrum disorder: a magnetic resonance imaging study of adults
Abstract
Background: Several prior reports have found that some young children with autism spectrum disorder [ASD; including autism and Asperger's syndrome and pervasive developmental disorder - not otherwise specified (PDD-NOS)] have a significant increase in head size and brain weight. However, the findings from older children and adults with ASD are inconsistent. This may reflect the relatively small sample sizes that were studied, clinical heterogeneity, or age-related brain differences.
Method: Hence, we measured head size (intracranial volume), and the bulk volume of ventricular and peripheral cerebrospinal fluid (CSF), lobar brain, and cerebellum in 114 people with ASD and 60 controls aged between 18 and 58 years. The ASD sample included 80 people with Asperger's syndrome, 28 with autism and six with PDD-NOS.
Results: There was no significant between-group difference in head and/or lobar brain matter volume. However, compared with controls, each ASD subgroup had a significantly smaller cerebellar volume, and a significantly larger volume of peripheral CSF.
Conclusions: Within ASD adults, the bulk volume of cerebellum is reduced irrespective of diagnostic subcategory. Also the significant increase in peripheral CSF may reflect differences in cortical maturation and/or ageing.
Similar articles
-
MRI-based morphometry in children with multiple complex developmental disorder, a phenotypically defined subtype of pervasive developmental disorder not otherwise specified.Psychol Med. 2008 Sep;38(9):1361-7. doi: 10.1017/S0033291707001481. Epub 2007 Sep 10. Psychol Med. 2008. PMID: 17825125
-
Altered chemical metabolites in the amygdala-hippocampus region contribute to autistic symptoms of autism spectrum disorders.Biol Psychiatry. 2007 Nov 1;62(9):1030-7. doi: 10.1016/j.biopsych.2007.05.015. Epub 2007 Jul 12. Biol Psychiatry. 2007. PMID: 17631869
-
Distinct patterns of grey matter abnormality in high-functioning autism and Asperger's syndrome.J Child Psychol Psychiatry. 2008 Dec;49(12):1287-95. doi: 10.1111/j.1469-7610.2008.01933.x. Epub 2008 Jul 29. J Child Psychol Psychiatry. 2008. PMID: 18673405
-
[Neuroanatomical basis of pervasive developmental disorders and its pathogenesis].Seishin Shinkeigaku Zasshi. 2008;110(10):893-9. Seishin Shinkeigaku Zasshi. 2008. PMID: 19195194 Review. Japanese.
-
[Autism spectrum disorders in adults].Ned Tijdschr Geneeskd. 2008 Jun 14;152(24):1365-9. Ned Tijdschr Geneeskd. 2008. PMID: 18664213 Review. Dutch.
Cited by
-
Identification and reduction of retained primitive reflexes by sensory stimulation in autism spectrum disorder: effects on qEEG networks and cognitive functions.BMJ Case Rep. 2023 Dec 28;16(12):e255285. doi: 10.1136/bcr-2023-255285. BMJ Case Rep. 2023. PMID: 38154865 Free PMC article.
-
A narrative sequencing and mentalizing training for adults with autism: A pilot study.Front Behav Neurosci. 2022 Aug 18;16:941272. doi: 10.3389/fnbeh.2022.941272. eCollection 2022. Front Behav Neurosci. 2022. PMID: 36062258 Free PMC article.
-
Retained Primitive Reflexes and Potential for Intervention in Autistic Spectrum Disorders.Front Neurol. 2022 Jul 7;13:922322. doi: 10.3389/fneur.2022.922322. eCollection 2022. Front Neurol. 2022. PMID: 35873782 Free PMC article. Review.
-
A 16-year study of longitudinal volumetric brain development in males with autism.Neuroimage. 2021 Aug 1;236:118067. doi: 10.1016/j.neuroimage.2021.118067. Epub 2021 Apr 18. Neuroimage. 2021. PMID: 33878377 Free PMC article.
-
A Novel Method for High-Dimensional Anatomical Mapping of Extra-Axial Cerebrospinal Fluid: Application to the Infant Brain.Front Neurosci. 2020 Oct 2;14:561556. doi: 10.3389/fnins.2020.561556. eCollection 2020. Front Neurosci. 2020. PMID: 33132824 Free PMC article.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical