Non-fluent progressive aphasia, depression, and OCD in a woman with progressive supranuclear palsy: neuroanatomical and neuropathological correlations
- PMID: 17182396
- DOI: 10.1080/13554790601125957
Non-fluent progressive aphasia, depression, and OCD in a woman with progressive supranuclear palsy: neuroanatomical and neuropathological correlations
Abstract
This paper details the case of a 64-year-old woman who presented to the psychiatry service with worsening mood in the context of a diagnosis of obsessive-compulsive disorder (OCD). On further examination she was found to have clinical findings consistent with frontotemporal lobar degeneration of the non-fluent progressive aphasia subtype. At post-mortem she was found to have progressive supranuclear palsy. We argue, in retrospect, that her OCD was likely prodromal to the development of her dementia. This case highlights the fact that frontotemporal lobar degeneration/progressive supranuclear palsy (FTLD/PSP) and other "tauopathies" represent a complex group of neurodegenerative disorders that may masquerade for many years as refractory psychiatric disorders.
Similar articles
-
Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP.Neurology. 2006 Jan 10;66(1):41-8. doi: 10.1212/01.wnl.0000191307.69661.c3. Neurology. 2006. PMID: 16401843
-
Diffusion tensor magnetic resonance imaging for single subject diagnosis in neurodegenerative diseases.Brain. 2013 Jul;136(Pt 7):2253-61. doi: 10.1093/brain/awt118. Epub 2013 May 31. Brain. 2013. PMID: 23729473
-
Are frontotemporal lobar degeneration, progressive supranuclear palsy and corticobasal degeneration distinct diseases?Nat Clin Pract Neurol. 2006 Dec;2(12):658-65. doi: 10.1038/ncpneuro0357. Nat Clin Pract Neurol. 2006. PMID: 17117169 Review.
-
Ubiquitin-positive frontotemporal lobar degeneration presenting with progressive Gogi (word-meaning) aphasia. A neuropsychological, radiological and pathological evaluation of a Japanese semantic dementia patient.J Neurol Sci. 2006 Dec 1;250(1-2):3-9. doi: 10.1016/j.jns.2006.05.067. Epub 2006 Oct 11. J Neurol Sci. 2006. PMID: 17045299
-
Neuropsychological assessment and differential diagnosis in young-onset dementias.Psychiatr Clin North Am. 2015 Jun;38(2):265-79. doi: 10.1016/j.psc.2015.01.003. Epub 2015 Mar 7. Psychiatr Clin North Am. 2015. PMID: 25998115 Review.
Cited by
-
Symptom-led staging for primary progressive aphasia.medRxiv [Preprint]. 2023 Mar 17:2023.03.13.23286972. doi: 10.1101/2023.03.13.23286972. medRxiv. 2023. Update in: Alzheimers Dement. 2024 Jan;20(1):195-210. doi: 10.1002/alz.13415. PMID: 36993460 Free PMC article. Updated. Preprint.
-
Automated Detection of Speech Timing Alterations in Autopsy-Confirmed Nonfluent/Agrammatic Variant Primary Progressive Aphasia.Neurology. 2022 Aug 2;99(5):e500-e511. doi: 10.1212/WNL.0000000000200750. Epub 2022 May 27. Neurology. 2022. PMID: 35914945 Free PMC article.
-
A presumptive association between obsessive compulsions and asymmetric temporal lobe atrophy: a case report.J Med Case Rep. 2022 Jan 20;16(1):21. doi: 10.1186/s13256-021-03228-z. J Med Case Rep. 2022. PMID: 35045865 Free PMC article.
-
Digital Speech Analysis in Progressive Supranuclear Palsy and Corticobasal Syndromes.J Alzheimers Dis. 2021;82(1):33-45. doi: 10.3233/JAD-201132. J Alzheimers Dis. 2021. PMID: 34219738 Free PMC article.
-
Which ante mortem clinical features predict progressive supranuclear palsy pathology?Mov Disord. 2017 Jul;32(7):995-1005. doi: 10.1002/mds.27034. Epub 2017 May 13. Mov Disord. 2017. PMID: 28500752 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous