Role of the Drosophila patched gene in positional signalling
- PMID: 1653906
- DOI: 10.1038/353184a0
Role of the Drosophila patched gene in positional signalling
Abstract
After cellularization of the Drosophila embryo, positional differences within each primordial segment are maintained and elaborated by processes that require cell interactions. The best-documented examples of such intercellular signalling are the mutual interactions between neighbouring cells expressing the homeodomain protein engrailed and the secreted glycoprotein encoded by wingless, the Drosophila homologue of the murine Wnt-1 gene. Little is known about the molecular basis of these signalling mechanisms but the activities of several other genes, notably patched and hedgehog, have been implicated in the process. Here we show that the role of patched in positional signalling is permissive rather than instructive, its activity being required to suppress wingless transcription in cells predisposed to express the latter. According to this view, expression of wingless is normally maintained only in those cells receiving an extrinsic signal, encoded by hedgehog, that antagonizes the repressive activity of patched. We suggest that the patched protein may itself be the receptor for this signal, implying that this is an unusual mechanism of ligand-dependent receptor inactivation.
Similar articles
-
Unrestricted expression of the Drosophila gene patched allows a normal segment polarity.Nature. 1991 Sep 12;353(6340):187-90. doi: 10.1038/353187a0. Nature. 1991. PMID: 1653907
-
patched overexpression causes loss of wingless expression in Drosophila embryos.Dev Biol. 1994 Jul;164(1):300-11. doi: 10.1006/dbio.1994.1200. Dev Biol. 1994. PMID: 8026632
-
Molecular characterization of a novel patched-related protein in Apis mellifera and Drosophila melanogaster.Arch Insect Biochem Physiol. 2008 Jul;68(3):156-70. doi: 10.1002/arch.20245. Arch Insect Biochem Physiol. 2008. PMID: 18563713
-
Morphogenetic signalling. Responses to hedgehog.Curr Biol. 1995 Jun 1;5(6):580-2. doi: 10.1016/s0960-9822(95)00114-x. Curr Biol. 1995. PMID: 7552160 Review.
-
Cell patterning in the Drosophila segment: engrailed and wingless antigen distributions in segment polarity mutant embryos.Dev Suppl. 1993:105-14. Dev Suppl. 1993. PMID: 8049466 Review.
Cited by
-
TnaA, a trithorax group protein, modulates wingless expression in different regions of the Drosophila wing imaginal disc.Sci Rep. 2023 Sep 13;13(1):15162. doi: 10.1038/s41598-023-42169-z. Sci Rep. 2023. PMID: 37704704 Free PMC article.
-
Hedgehog-Related Mutation Causes Bone Malformations with or without Hereditary Gene Mutations.Int J Mol Sci. 2023 Aug 17;24(16):12903. doi: 10.3390/ijms241612903. Int J Mol Sci. 2023. PMID: 37629084 Free PMC article. Review.
-
The Inseparable Relationship Between Cholesterol and Hedgehog Signaling.Annu Rev Biochem. 2023 Jun 20;92:273-298. doi: 10.1146/annurev-biochem-052521-040313. Epub 2023 Mar 31. Annu Rev Biochem. 2023. PMID: 37001135 Free PMC article. Review.
-
Drosophila hedgehog signaling range and robustness depend on direct and sustained heparan sulfate interactions.Front Mol Biosci. 2023 Feb 22;10:1130064. doi: 10.3389/fmolb.2023.1130064. eCollection 2023. Front Mol Biosci. 2023. PMID: 36911531 Free PMC article.
-
Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient.Nat Commun. 2023 Feb 10;14(1):758. doi: 10.1038/s41467-023-36450-y. Nat Commun. 2023. PMID: 36765094 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases