Adipose tissue, adipokines, and inflammation
- PMID: 15867843
- DOI: 10.1016/j.jaci.2005.02.023
Adipose tissue, adipokines, and inflammation
Abstract
White adipose tissue is no longer considered an inert tissue mainly devoted to energy storage but is emerging as an active participant in regulating physiologic and pathologic processes, including immunity and inflammation. Macrophages are components of adipose tissue and actively participate in its activities. Furthermore, cross-talk between lymphocytes and adipocytes can lead to immune regulation. Adipose tissue produces and releases a variety of proinflammatory and anti-inflammatory factors, including the adipokines leptin, adiponectin, resistin, and visfatin, as well as cytokines and chemokines, such as TNF-alpha, IL-6, monocyte chemoattractant protein 1, and others. Proinflammatory molecules produced by adipose tissue have been implicated as active participants in the development of insulin resistance and the increased risk of cardiovascular disease associated with obesity. In contrast, reduced leptin levels might predispose to increased susceptibility to infection caused by reduced T-cell responses in malnourished individuals. Altered adipokine levels have been observed in a variety of inflammatory conditions, although their pathogenic role has not been completely clarified.
Similar articles
-
Functional and structural features of adipokine family.Cytokine. 2013 Jan;61(1):1-14. doi: 10.1016/j.cyto.2012.08.036. Epub 2012 Sep 27. Cytokine. 2013. PMID: 23022179 Review.
-
Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome.Mol Cell Endocrinol. 2010 Jan 15;314(1):1-16. doi: 10.1016/j.mce.2009.07.031. Epub 2009 Aug 12. Mol Cell Endocrinol. 2010. PMID: 19682539 Review.
-
Adipokines: the missing link between insulin resistance and obesity.Diabetes Metab. 2008 Feb;34(1):2-11. doi: 10.1016/j.diabet.2007.09.004. Diabetes Metab. 2008. PMID: 18093861 Review.
-
Recent advances in the relationship between obesity, inflammation, and insulin resistance.Eur Cytokine Netw. 2006 Mar;17(1):4-12. Eur Cytokine Netw. 2006. PMID: 16613757 Review.
-
Insulin resistance in type 2 diabetes -- role of the adipokines.Curr Mol Med. 2005 May;5(3):333-9. doi: 10.2174/1566524053766022. Curr Mol Med. 2005. PMID: 15892652 Review.
Cited by
-
Association between lipid accumulation product and psoriasis among adults: a nationally representative cross-sectional study.Lipids Health Dis. 2024 May 17;23(1):143. doi: 10.1186/s12944-024-02123-y. Lipids Health Dis. 2024. PMID: 38760661 Free PMC article.
-
Protein Intake and Physical Activity Levels as Determinants of Sarcopenia Risk in Community-Dwelling Older Adults.Nutrients. 2024 May 2;16(9):1380. doi: 10.3390/nu16091380. Nutrients. 2024. PMID: 38732628 Free PMC article.
-
Diet-Induced Early Inflammatory Response of Visceral Adipose Tissue in Healthy Male Wistar Rats.Nutrients. 2024 Apr 16;16(8):1184. doi: 10.3390/nu16081184. Nutrients. 2024. PMID: 38674875 Free PMC article.
-
Effect of Physical Activity during Pregnancy on the Risk of Hypertension Disorders and Gestational Diabetes: Evidence Generated by New RCTs and Systematic Reviews.J Clin Med. 2024 Apr 11;13(8):2198. doi: 10.3390/jcm13082198. J Clin Med. 2024. PMID: 38673471 Free PMC article. Review.
-
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options (Review).Mol Med Rep. 2024 Jun;29(6):95. doi: 10.3892/mmr.2024.13219. Epub 2024 Apr 12. Mol Med Rep. 2024. PMID: 38606791 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous