Reactive hypoglycemia in lean young women with PCOS and correlations with insulin sensitivity and with beta cell function
- PMID: 15808380
- DOI: 10.1016/j.ejogrb.2004.07.038
Reactive hypoglycemia in lean young women with PCOS and correlations with insulin sensitivity and with beta cell function
Abstract
Reactive hypoglycemia (RH), which is a postprandial hypoglycemic state, occurs within 2-5 h after food intake. It is classified as idiopathic, alimentary, or diabetic reactive hypoglycemia. We studied the incidence of reactive hypoglycemia and looked for any correlations between it and the presence of insulin sensitivity and/or beta cell function in young lean polycystic ovary syndrome (PCOS) patients. This study was designed as a cross-sectional study in 64 lean young women with PCOS (BMI < or = 25 kg/m2). Various indices of insulin sensitivity and beta cell function derived from the oral glucose tolerance test (OGTT) results were used. We found the rate of RH to be 50% in lean young women with PCOS. DHEA-S and PRL levels were found to be lower in subjects with RH (P < 0.05 and P > 0.05, respectively). Beta cell function indices such as the insulinogenic index (at 120 min), CIR (at 120 min) and HOMA beta cell index were found to be insignificantly higher in the RH group than the nonreactive hypoglycemia (NRH) group. The 4 h glucose level, but not the 3 h glucose level, was significantly correlated with insulin resistance indices, such as fasting insulin level, HOMA-IR, Quicky index, and FIRI in the RH group. Significantly decreased DHEA-S levels were an interesting finding. In conclusion, there is an urgent need to investigate RH in lean young women with PCOS. Our results indicate that more definite insulin resistance occurs in subjects with RH in the fourth hour of the OGTT than those with RH in the third hour. In addition, RH in the fourth hour together with a low DHEA-S level may be predictive of future diabetes in young women with PCOS even when they are not obese.
Similar articles
-
Abnormal response of insulin to glucose loading and assessment of insulin resistance in non-obese patients with polycystic ovary syndrome.Gynecol Endocrinol. 2008 Jul;24(7):385-91. doi: 10.1080/09513590802173584. Gynecol Endocrinol. 2008. PMID: 18645711
-
Analysis of clinical characteristics in large-scale Chinese women with polycystic ovary syndrome.Neuro Endocrinol Lett. 2007 Dec;28(6):807-10. Neuro Endocrinol Lett. 2007. PMID: 18063948
-
Insulin response to oral glucose in healthy, lean young women and patients with polycystic ovary syndrome.Gynecol Endocrinol. 2008 Nov;24(11):637-43. doi: 10.1080/09513590802342858. Gynecol Endocrinol. 2008. PMID: 19031221
-
Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls.Obstet Gynecol Surv. 2004 Feb;59(2):141-54. doi: 10.1097/01.OGX.0000109523.25076.E2. Obstet Gynecol Surv. 2004. PMID: 14752302 Review.
-
Glucose intolerance in the polycystic ovary syndrome: role of the pancreatic beta-cell.J Pediatr Endocrinol Metab. 2000;13 Suppl 5:1299-301. J Pediatr Endocrinol Metab. 2000. PMID: 11117674 Review.
Cited by
-
SHBG Levels Do Not Correlate with Insulin Levels in PCOS with Appropriate Fasting Insulin Sensitivity.J Clin Med. 2024 Feb 1;13(3):838. doi: 10.3390/jcm13030838. J Clin Med. 2024. PMID: 38337532 Free PMC article.
-
Reactive Hypoglycemia: A Trigger for Nutrient-Induced Endocrine and Metabolic Responses in Polycystic Ovary Syndrome.J Clin Med. 2023 Nov 23;12(23):7252. doi: 10.3390/jcm12237252. J Clin Med. 2023. PMID: 38068304 Free PMC article.
-
Pathology of hyperandrogenemia in the oocyte of polycystic ovary syndrome.Steroids. 2022 Apr;180:108989. doi: 10.1016/j.steroids.2022.108989. Epub 2022 Feb 18. Steroids. 2022. PMID: 35189133 Free PMC article. Review.
-
The Detection of Postprandial Hypoglycemia with 5-Hour Oral Glucose Tolerance Test.EJIFCC. 2021 Dec 7;32(4):451-457. eCollection 2021 Dec. EJIFCC. 2021. PMID: 35046763 Free PMC article.
-
Postprandial Reactive Hypoglycemia.Sisli Etfal Hastan Tip Bul. 2019 Aug 28;53(3):215-220. doi: 10.14744/SEMB.2019.59455. eCollection 2019. Sisli Etfal Hastan Tip Bul. 2019. PMID: 32377086 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical