Reduced basal forebrain and hippocampal activation during memory encoding in girls with fragile X syndrome
- PMID: 15232287
- DOI: 10.1097/01.wnr.0000134472.44362.be
Reduced basal forebrain and hippocampal activation during memory encoding in girls with fragile X syndrome
Abstract
Fragile X syndrome (FraX), the most common heritable cause of developmental disability, is associated with IQ, memory, and visuospatial processing deficits. The fragile X gene (FMR1) is prominently transcribed in two regions critical to memory encoding and attention: the hippocampus and the basal forebrain. To probe functional MRI activation abnormalities associated with the disorder, girls with FraX and age-matched, normally-developing girls were scanned during a test of visual memory encoding. While there were considerable similarities in activation patterns between the two groups, the girls with FraX showed significantly less activation in the hippocampus and the basal forebrain. This is the first study, to our knowledge, demonstrating functional deficits in FraX subjects in brain regions known to have the highest FMR1 transcription.
Similar articles
-
Functional neuroanatomy of visuospatial working memory in fragile X syndrome: relation to behavioral and molecular measures.Am J Psychiatry. 2001 Jul;158(7):1040-51. doi: 10.1176/appi.ajp.158.7.1040. Am J Psychiatry. 2001. PMID: 11431225
-
Functional brain activation during arithmetic processing in females with fragile X Syndrome is related to FMR1 protein expression.Hum Brain Mapp. 2002 Aug;16(4):206-18. doi: 10.1002/hbm.10048. Hum Brain Mapp. 2002. PMID: 12112763 Free PMC article.
-
Frontostriatal deficits in fragile X syndrome: relation to FMR1 gene expression.Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3615-20. doi: 10.1073/pnas.0304544101. Epub 2004 Mar 1. Proc Natl Acad Sci U S A. 2004. PMID: 14993603 Free PMC article.
-
Imaging the human medial temporal lobe with high-resolution fMRI.Neuron. 2010 Feb 11;65(3):298-308. doi: 10.1016/j.neuron.2009.12.022. Neuron. 2010. PMID: 20159444 Free PMC article. Review.
-
A developmental approach to understanding Fragile X syndrome in females.Microsc Res Tech. 2002 May 1;57(3):179-86. doi: 10.1002/jemt.10070. Microsc Res Tech. 2002. PMID: 12112455 Review.
Cited by
-
TRRAP-mediated acetylation on Sp1 regulates adult neurogenesis.Comput Struct Biotechnol J. 2022 Dec 19;21:472-484. doi: 10.1016/j.csbj.2022.12.024. eCollection 2023. Comput Struct Biotechnol J. 2022. PMID: 36618986 Free PMC article.
-
FMRP-Driven Neuropathology in Autistic Spectrum Disorder and Alzheimer's disease: A Losing Game.Front Mol Biosci. 2021 Oct 25;8:699613. doi: 10.3389/fmolb.2021.699613. eCollection 2021. Front Mol Biosci. 2021. PMID: 34760921 Free PMC article. Review.
-
Autism in Fragile X Syndrome; A Functional MRI Study of Facial Emotion-Processing.Genes (Basel). 2019 Dec 17;10(12):1052. doi: 10.3390/genes10121052. Genes (Basel). 2019. PMID: 31861230 Free PMC article.
-
Brain circuitry, behavior, and cognition: A randomized placebo-controlled trial of donepezil in fragile X syndrome.J Psychopharmacol. 2019 Aug;33(8):975-985. doi: 10.1177/0269881119858304. Epub 2019 Jul 2. J Psychopharmacol. 2019. PMID: 31264943 Free PMC article. Clinical Trial.
-
Hippocampal deficits in neurodevelopmental disorders.Neurobiol Learn Mem. 2019 Nov;165:106945. doi: 10.1016/j.nlm.2018.10.001. Epub 2018 Oct 12. Neurobiol Learn Mem. 2019. PMID: 30321651 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical