Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2004 Feb;118(1):223-36.
doi: 10.1037/0735-7044.118.1.223.

Blockade of central cholinergic receptors impairs new learning and increases proactive interference in a word paired-associate memory task

Alireza Atri  1 , Seth Sherman, Kenneth A Norman, Brenda A Kirchhoff, Marlene M Nicolas, Michael D Greicius, Steven C Cramer, Hans C Breiter, Michael E Hasselmo, Chantal E Stern
Affiliations
Comparative Study

Blockade of central cholinergic receptors impairs new learning and increases proactive interference in a word paired-associate memory task

Alireza Atri et al. Behav Neurosci. 2004 Feb.

Abstract

Experimental data and computational models suggest that blockade of muscarinic cholinergic receptors impairs paired-associate learning and increases proactive interference (E. DeRosa & M. E. Hasselmo, 2000; M. E. Hasselmo & J. M. Bower, 1993). The results presented here provide evidence in humans supporting these hypotheses. Young healthy subjects first learned baseline word pairs (A-B) and, after a delay, learned additional overlapping (A-C) and nonoverlapping (D-E) word pairs. As predicted, when compared with subjects who received the active placebo glycopyrrolate (4 microg/kg) and subjects who were not injected, those who received scopolamine (8 microg/kg) showed (a) overall impairment in new word paired-associate learning, but no impairment in cued recall of previously learned associates; and (b) greater impairment in learning overlapping (A-C) compared with nonoverlapping (D-E) paired associates.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

Substances