Epidemiology of triglycerides: a view from Framingham
- PMID: 1466315
- DOI: 10.1016/0002-9149(92)91083-g
Epidemiology of triglycerides: a view from Framingham
Abstract
New analyses from the Framingham Heart Study are presented showing that men and women who have high triglyceride levels (> 1.7 mmol/liter) and a low high-density lipoprotein (HDL) level (< 1.03 mmol/liter) run a significantly higher rate of coronary artery disease and can be identified, and that this risk group (high triglyceride-low HDL) is, independently of the major risk factors (including low HDL), related to occurrence of coronary artery disease. Further, this trait appears to be common in our society, producing twice as many cases of coronary artery disease during the 14 years of the Framingham study as the next highest disease-producing lipid abnormality. This trait of high triglyceride-low HDL is associated in the medical literature with increased insulin resistance, higher blood sugars (within the normal range), higher uric acid levels, hypertension, and centrally mediated obesity. Because total cholesterol in people with these traits may be less than or just slightly greater than 5.2 mmol/liter, they are missed or neglected by most cholesterol screening programs.
Comment in
-
Triglycerides, high-density lipoproteins and the Framingham Heart Study.Am J Cardiol. 1993 Aug 1;72(3):371. doi: 10.1016/0002-9149(93)90693-7. Am J Cardiol. 1993. PMID: 8342525 No abstract available.
Similar articles
-
Triglyceride as a risk factor for coronary artery disease.Am J Cardiol. 1998 Nov 5;82(9A):22Q-25Q. doi: 10.1016/s0002-9149(98)00770-x. Am J Cardiol. 1998. PMID: 9819100 Review.
-
Lipid screening: is it enough to measure total cholesterol concentration?BMJ. 1990 Sep 22;301(6752):584-7. doi: 10.1136/bmj.301.6752.584. BMJ. 1990. PMID: 2082960 Free PMC article.
-
Low high-density lipoprotein cholesterol and other coronary heart disease risk factors in patients with total cholesterol levels greater than 5.17 mmol/L (200 mg/dL) in family practice. A report from CEN.J Am Board Fam Pract. 1991 Sep-Oct;4(5):285-97. J Am Board Fam Pract. 1991. PMID: 1746296 Clinical Trial.
-
Hypertriglyceridemia: risks and perspectives.Am J Cardiol. 1992 Dec 14;70(19):19H-25H. doi: 10.1016/0002-9149(92)91086-j. Am J Cardiol. 1992. PMID: 1466313 Review.
-
Triglyceride levels and the risk of coronary artery disease: a view from Australia.Am J Cardiol. 1992 Dec 14;70(19):14H-18H. doi: 10.1016/0002-9149(92)91085-i. Am J Cardiol. 1992. PMID: 1466312
Cited by
-
Fasting Triglycerides in the Upper Normal Range Are Independently Associated with an Increased Risk of Diabetes Mortality in a Large Representative US Population.J Cardiovasc Dev Dis. 2024 Apr 21;11(4):128. doi: 10.3390/jcdd11040128. J Cardiovasc Dev Dis. 2024. PMID: 38667746 Free PMC article.
-
Significance of Circulating Remnant Lipoprotein Cholesterol Levels Measured by Homogeneous Assay in Patients with Type 2 Diabetes.Biomolecules. 2023 Mar 3;13(3):468. doi: 10.3390/biom13030468. Biomolecules. 2023. PMID: 36979403 Free PMC article.
-
A Clinical Case of a Homozygous Deletion in the APOA5 Gene with Severe Hypertriglyceridemia.Genes (Basel). 2022 Jun 14;13(6):1062. doi: 10.3390/genes13061062. Genes (Basel). 2022. PMID: 35741823 Free PMC article.
-
Effects of Daily Consumption of an Aqueous Dispersion of Free-Phytosterols Nanoparticles on Individuals with Metabolic Syndrome: A Randomised, Double-Blind, Placebo-Controlled Clinical Trial.Nutrients. 2020 Aug 10;12(8):2392. doi: 10.3390/nu12082392. Nutrients. 2020. PMID: 32785036 Free PMC article. Clinical Trial.
-
The association between triglycerides and incident cardiovascular disease: What is "optimal"?J Clin Lipidol. 2020 Jul-Aug;14(4):438-447.e3. doi: 10.1016/j.jacl.2020.04.009. Epub 2020 May 6. J Clin Lipidol. 2020. PMID: 32571728 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
