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Case Reports
. 2011 Jan;4(1):24-8.

Pancreatic Adenocarcinoma Associated With Werner's Syndrome (Adult-Onset Progeria)

Stephen G Chun, Nelson S Yee, John M Holland, Ralph V Shohet, Melvin P Palalay, Peter K Bryant-Greenwood
Case Reports

Pancreatic Adenocarcinoma Associated With Werner's Syndrome (Adult-Onset Progeria)

Stephen G Chun et al. Gastrointest Cancer Res. 2011 Jan.
No abstract available

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Figures

Figure 1.
Figure 1.
The patient appeared decades older than his stated age on physical examination with “bird-like facies,” thin white hair, dermal and muscle atrophy, wrinkled skin, and plantar hyperkeratosis (black arrow).
Figure 2.
Figure 2.
Photographs of the patient at various stages of his life revealed accelerated aging with onset at adolescence that is classic of Werner's Syndrome.
Figure 3.
Figure 3.
A CT-scan of the abdomen showed a 2-cm hypodense mass at the head of the pancreas.
Figure 4.
Figure 4.
Histologic analyses of the pancreatic tumor. (A) The CT-guided percutaneous biopsy of the mass in the pancreatic head revealed moderately differentiated pancreatic adenocarcinoma. (B) The primary tumor exhibited perineural invasion (black arrows) and desmoplastic reaction in the setting of chronic pancreatitis. (C) Microscopic examination of liver tissue revealed tumor metastasis. (D) Metastatic tumor on microscopic examination of lung tissue.
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