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Population genetics is the study of the genetic composition of populations, including distributions and changes in genotype and phenotype frequency in response to the processes of natural selection, genetic drift, mutation and gene flow.
Two groups of scientists independently engineer gene drives in Arabidopsis thaliana, demonstrating the possibility for spreading fitness-reducing genetic modifications through wild populations of plants for population suppression.
The generation of a de novo contiguous reference genome for the African buffalo reveals that continent wide population structure is influenced by isolation by distance, and signatures of selection suggest a strong effect of infectious disease.
Trans-species polymorphisms (TSP) in disease loci are thought to be caused by long-term host-parasite coevolution. Here, the authors identify consistent TSPs across three species of Daphnia and find several genes related to immunity function for resistance to a virulent bacterial pathogen.
Analysis of 297 whole-genome sequences of six introduced European rabbit populations, domestic rabbits and wild rabbits from the native range shows wild and domestic ancestry in introduced rabbit populations and purging of alleles for domesticated traits when rabbits colonized novel natural environments.
Petrazzini et al. leverage exome sequencing data and a novel machine learning-based marker to identify rare and ultra-rare coding variants associated with coronary artery disease.
Two groups of scientists independently engineer gene drives in Arabidopsis thaliana, demonstrating the possibility for spreading fitness-reducing genetic modifications through wild populations of plants for population suppression.
In this Comment, Lamkin and Gymrek discuss recent results that suggest that the systematic incorporation of tandem repeats into complex trait analyses will yield a rich source of causal variants and new biological insights.