Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
C–H activation in long-chain organic molecules remains largely unexplored. Here, the authors report light-driven C–H activation mediated by 2D TMDCs and the resultant synthesis of luminescent carbon dots.
Researchers using femtosecond lasers generate offset-free THz pulses to phase-lock the electronic oscillators. This enables the phase-resolved measurement of the emitted THz pulses with sub-cycle time resolution. Ultrafast dynamic response, such as anti-phase locking behavior, is also observed.
The study reveals defective maternal mRNA deadenylation in oocytes matured in culture dishes versus natural ones, potentially explaining lower fertility in assisted reproduction with immature oocytes.
Brain iron accumulation has been associated with multiple brain disorders, but the mechanism is not well understood. Here, the authors investigate the genetic determinants of brain iron accumulation and their implications for neuropsychiatric disorders.
Most studies on HIV-1 proviruses that persist during antiretroviral therapy have focused on males with HIV-1 subtype B, even though the majority of people living with HIV globally have non-B subtypes. Here, the authors describe the proviral genetic landscape of HIV-1 subtypes A1 and D in Ugandan females and males using near-full-length proviral sequencing. The authors also describe a molecular assay for intact proviral quantification of these HIV-1 subtypes.
Rapid hemostasis of deep noncompressible irregularly shaped trauma wounds is challenging. Here the authors report a neutrophil extracellular traps (NETs)-inspired DNA hydrogel that is able to induce NETs-like thrombosis as a physical blockade and biological clot to arrest bleeding in deep tissues.
Authors realize a tunable hybrid improper ferroelectricity in [La2NiMnO6/La2CoMnO6]n double perovskite superlattices at room temperature by a strain-driven oxygen octahedral distortion strategy.
Cryo-EM is an experimental technique for uncovering protein structural and dynamic properties. Here, authors propose a neural network model to infer the structural flexibility of proteins from cryo-EM, demonstrating high accuracy and efficiency.
Here the authors report a terahertz detector with a Q value of 1017, embedded in a Tamm cavity and offers a 469 MHz bandwidth. It features an Nb5N6 microbolometer in an Si/air DBR and metal reflector, with tunable resonant frequency via substrate layer thickness.
The glaciers of Juneau Icefield, Alaska are reconstructed from 1770 to 2020 AD. Ice loss has accelerated dramatically, with a number of positive feedbacks now happening that accelerate ice loss and inhibit future stabilisation and regrowth.
The meninges are a structure within the central nervous system that protects and provides supportive functions. Here they identify a population of meningeal lymphatic supporting cells within the zebrafish leptomeninges and characterize their roles in supporting mural lymphatic endothelial cell development and homeostasis.
Plant-parasitic nematodes have the potential to destroy crops globally, and limited options for managing nematode infestation are available. Here, the authors report the 1,3,4-oxadiazole thioether scaffold called Cyprocide that selectively kills nematodes including diverse species of plant-parasitic nematodes.
Here, Chevalier et al show that Streptococcus pneumoniae induces the histone modifications H3K4me2 in epithelial cells, where it persists beyond bacterial clearance and affects cell responses to secondary infection.
Targeted protein degradation harnessing the ubiquitin system is a groundbreaking modality in drug discovery. Here, the authors identify cellular signaling pathways, such as PARG, PERK, or HSP90, that modulate the targeted degradation of the anticancer targets such as BRD4 induced by PROTACs.
Here authors present a distribution of oriented pores and single crystalline array structures in the presence of abundant acid sites in ZSM-5 nanorod arrays grown on monoliths. Enhanced dynamics and improved capacity are exhibited simultaneously in propene capture at low temperature within a short duration.
Chiral multiferroics are rare materials. Here the authors report that ferroelectric, magnetic orders, and chirality coexist in copper hybrid perovskites and reveal a hybrid-improper chiral transfer mechanism by defining a pseudo-scalar order parameter.
Plasma samples from 324 Black and 1,547 white participants underwent analysis with C2N Diagnostics’ Precivity AD test for Aβ42 and Aβ40. Compared to white individuals, Black individuals had higher average plasma Aβ42/40 levels at baseline, consistent with a lower average level of amyloid pathology.
How conflicting contingencies between stimulus and outcome can be resolved by attention are not fully understood. Here authors, combining computational model and experimental approaches, show that mouse anterior cingulate cortex (ACC) effectively operates on low-dimensional neuronal subspaces to combine stimulus-related information with internal cues to drive actions under conflict.
Benoit et al. present high-resolution structures of dimeric microtubule-bound KIF1A, including its pathogenic P305L mutant. Their findings provide insights into KIF1A’s motility mechanism and potential therapies for associated neurological disorders.
Dopamine regulates multiple brain functions through coexisting tonic and phasic release modalities. Here, the authors describe an approach for monitoring tonic and phasic dopamine release simultaneously via on-demand chemogenetic tuning of a dopamine sensor.