Methods for the asymmetric functionalization of unstrained C(sp3)–C(sp3) bonds are rare. Now, strategies are developed for the enantioselective functionalization of allylic C(sp3)–C(sp3) bonds with a palladium catalyst through either kinetic resolution or dynamic kinetic asymmetric transformation.
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References
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This is a summary of: Chen, Y.-W. et al. Intermolecular asymmetric functionalization of unstrained C(sp3)–C(sp3) bonds in allylic substitution reactions. Nat. Synth. https://doi.org/10.1038/s44160-024-00555-z (2024).
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Asymmetric allylic C(sp3)–C(sp3) bond functionalization. Nat. Synth (2024). https://doi.org/10.1038/s44160-024-00556-y
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DOI: https://doi.org/10.1038/s44160-024-00556-y
