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Biocatalysis

Order matters in evolution

Nature Catalysis volume 7, pages 467–468 (2024)Cite this article

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The understanding of protein evolution is a central challenge in biology. Now, the evolution of a β-lactamase in vitro reveals that the total effect of mutations can change the rate-limiting step of the catalytic mechanism.

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Fig. 1: Epistasis is rooted in changes in the catalytic cycle.

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Authors and Affiliations

  1. Instituto de Biología Molecular y Celular de Rosario (IBR, CONICET-UNR), Ocampo and Esmeralda, Rosario, Argentina

    Gina Dotta & Alejandro J. Vila

  2. Área Biofísica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Rosario, Argentina

    Alejandro J. Vila

Authors
  1. Gina Dotta
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  2. Alejandro J. Vila
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Correspondence to Alejandro J. Vila.

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The authors declare no competing interests.

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Dotta, G., Vila, A.J. Order matters in evolution. Nat Catal 7, 467–468 (2024). https://doi.org/10.1038/s41929-024-01163-y

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