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HIV

Germline-targeting immunogens guide bnAb development

Nature Immunology volume 25, pages 944–946 (2024)Cite this article

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Structure-guided protein design enables germline-targeting immunization strategies to generate broadly neutralizing antibodies against MPER, a region of the HIV envelope glycoprotein that is functionally important and highly conserved, but a challenging target for antibody responses.

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Fig. 1: Immunization with MPER germline-targeting immunogens.

References

  1. Burton, D. R. & Hangartner, L. Annu. Rev. Immunol. 34, 635–659 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Sneller, M. C. et al. Nature 606, 375–381 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Schiffner, T. et al. Nat. Immunol. https://doi.org/10.1038/s41590-024-01833-w (2024).

    Article  PubMed  Google Scholar 

  4. Ray, R. et al. Nat. Immunol. https://doi.org/10.1038/s41590-024-01844-7 (2024).

    Article  PubMed  Google Scholar 

  5. Julien, J.-P. et al. Science 342, 1477–1483 (2013).

    Article  CAS  PubMed  Google Scholar 

  6. Haynes, B. F. et al. Nat. Rev. Immunol. 23, 142–158 (2023).

    Article  CAS  PubMed  Google Scholar 

  7. Huang, J. et al. Nature 491, 406–412 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Jardine, J. G. et al. Science 351, 1458–1463 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Leggat, D. J. et al. Science 378, eadd6502 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA

    Tobias V. Lanz

  2. Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA

    Tobias V. Lanz

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  1. Tobias V. Lanz
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Correspondence to Tobias V. Lanz.

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The author declares no competing interests.

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Lanz, T.V. Germline-targeting immunogens guide bnAb development. Nat Immunol 25, 944–946 (2024). https://doi.org/10.1038/s41590-024-01852-7

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