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Progression-free survival end points in prostate cancer: are we truly making progress

Nature Reviews Urology (2024)Cite this article

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Recently, several therapeutic strategies in prostate cancer have been granted regulatory approval based on progression-free survival benefits alone, which is a relative change in the therapeutic development of prostate cancer treatments. Previously, overall survival was a requirement for approvals. Whether this approach is warranted or beneficial to patients remains unclear.

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Authors and Affiliations

  1. Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, USA

    Ravi A. Madan

  2. Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Edwin M. Posadas

  3. Department of Medicine, Harvard Medical School, Massachusetts General Hospital Cancer Center, Boston, MA, USA

    Richard J. Lee

Authors
  1. Ravi A. Madan
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  2. Edwin M. Posadas
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  3. Richard J. Lee
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Correspondence to Ravi A. Madan.

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The authors declare no competing interests.

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Madan, R.A., Posadas, E.M. & Lee, R.J. Progression-free survival end points in prostate cancer: are we truly making progress. Nat Rev Urol (2024). https://doi.org/10.1038/s41585-024-00902-x

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