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Basics, benefits, and pitfalls of pupillometers assessing visual function

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Abstract

Numerous commercially and non-commercially available pupillometers are nowadays able to assess various biological functions in humans, by evaluating pupils’ dynamics in response to specific stimuli. However, the use of pupillometers for ophthalmic afferent evaluations (i.e., photoreceptoral responses) in real-world settings is relatively limited. Recent scientific and technological advances, coupled with artificial intelligence methods have improved the performance of such devices to objectively detect, quantify, and classify functional disturbances of the retina and the optic nerve. This review aims to summarize the scientific principles, indications, outcomes, and current limitations of pupillometry used for evaluation of afferent pathways in ophthalmic clinical settings.

摘要

如今, 大量用于商业和非商业的瞳孔测量仪能够通过评估瞳孔对特定刺激的动力学反应来评估各种生物学功能。然而, 真实世界中瞳孔测量仪在视觉传入系统 (即光感受器反应) 方面的应用相对有限。当前科技进步和人工智能可提高这些设备的性能, 能够客观地检测、量化和分类视网膜和视神经的功能障碍。本综述旨在总结瞳孔测量仪在眼科临床应用中用于评估视觉传入系统的科学原理、适应症、结果和局限性。

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Fig. 1: Generic graph representing the pupillary light response (PLR) and associated parameters allowing its quantification (i.e., maximum pupillary constriction, latency, post-illumination pupillary response at 6 s after light cessation), in a normal eye (black) and in glaucoma (blue).

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Acknowledgements

We thank Ayse Gungor for her contribution to the figure drawing.

Author information

Authors and Affiliations

  1. Rothschild Foundation Hospital, Paris, France

    Manon Philibert & Dan Milea

  2. Copenhagen University Hospital, Copenhagen, Denmark

    Dan Milea

  3. Singapore National Eye Centre, Singapore, Singapore

    Dan Milea

  4. Angers University Hospital, Angers, France

    Dan Milea

  5. Duke-NUS Medical School, Singapore, Singapore

    Dan Milea

  6. Singapore Eye Research Institute, Singapore, Singapore

    Dan Milea

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  1. Manon Philibert
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  2. Dan Milea
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MP has contributed with data collection, selection, and article writing. DM has contributed with the conception, writing, and article editing.

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Correspondence to Dan Milea.

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Philibert, M., Milea, D. Basics, benefits, and pitfalls of pupillometers assessing visual function. Eye (2024). https://doi.org/10.1038/s41433-024-03151-9

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